ERİŞKİN YAŞTA GELEN ÇOCUKLUK ÇAĞI VE ADOLESAN KANSER HASTALARINDA DİĞER NONREPRODÜKTİF ENDOKRİN ANORMALLİKLER

Yıl 2011, Cilt: 14 Sayı: 4, 91 - 95, 01.10.2011

Özgür Öktem Bülent Urman

Öz

Erişkin yaşa gelen çocukluk çağı kanser hastalarında tedaviye
bağlı olarak pekçok sitemik ve endokrin bozukluk izlenmektedir.
Malesef kız cinsiyet bu olumsuzluklardan daha fazla pay almaktadır.
Özellikle kraniospinal radyasyon sonrası, kognitif bozukluklar, obesite,
kardiovasküler hastalık, pubertenin zamanlamasına aksaklık,
tiroid fonskiyon bozuklukları, iskelet büyümesinde gerilik bunlardan
bir kaçıdır. Bu bülümde bu hastalarda uzun dönemde görülen üreme
dışı endokrin anormallikler işlenecektir.

OTHER LONG-TERM ENDOCRINE ABNORMALITIES IN THE CHILDHOOD CANCER SURVIVORS

Öz

There are numerous treatment-related risks for long-term adverse
outcomes among survivors of childhood cancer after exposure to
chemotherapeutic drugs and radiotherapy. Sadly, It appears that female
sex is more commonly associated with treatment related risks such as
cognitive dysfunction after cranial irradiation, poor cardiovascular outcomes,
obesity, radiation-associated differences in pubertal timing,
development of primary hypothyroidism, impaired skeletal growth
breast cancer as a second malignant neoplasm, and osteonecrosis.

Kaynakça

• 1. Oeffinger, K C, Mertens, A C, Sklar, C A, et al., Chronic health conditions in adult survivors of childhood cancer. N Engl J Med 2006; 355: 1572-82.
• 2. Chemaitilly, W and Sklar, C A, Endocrine complications in long-term survivors of childhood cancers. Endocr Relat Cancer 2010; 17: R141-59.
• 3. Diller, L, Chow, E J, Gurney, J G, et al., Chronic disease in the Childhood Cancer Survivor Study cohort: a review of published findings. J Clin Oncol 2009; 27: 2339-55.
• 4. Armstrong, G T, Whitton, J A, Gajjar, A, et al., Abnormal timing of menarche in survivors of central nervous system tumors: A report from the Childhood Cancer Survivor Study. Cancer 2009; 115: 2562-70.
• 5. Oberfield, S E, Soranno, D, Nirenberg, A, et al., Age at onset of puberty following high-dose central nervous system radiation therapy. Arch Pediatr Adolesc Med 1996; 150: 589-92.
• 6. Berberoglu, M, Precocious Puberty and Normal Variant Puberty: Definition, etiology, diagnosis and current management. J Clin Res Pediatr Endocrinol 2009; 1: 164-74.
• 7. Green, D M, Sklar, C A, Boice, J D, Jr., et al., Ovarian failure and reproductive outcomes after childhood cancer treatment: results from the Childhood Cancer Survivor Study. J Clin Oncol 2009; 27: 2374-81.
• 8. Byrne, J, Fears, T R, Mills, J L, et al., Fertility in women treated with cranial radiotherapy for childhood acute lymphoblastic leukemia. Pediatr Blood Cancer 2004; 42: 589-97.
• 9. Taylor, R E, Cancer in children: radiotherapeutic approaches. Br Med Bull 1996; 52: 873-86.
• 10. Gurney, J G, Ness, K K, Stovall, M, et al., Final height and body mass index among adult survivors of childhood brain cancer: childhood cancer survivor study. J Clin Endocrinol Metab 2003; 88: 4731-9.
• 11. Garmey, E G, Liu, Q, Sklar, C A, et al., Longitudinal changes in obesity and body mass index among adult survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study. J Clin Oncol 2008; 26: 4639-45.
• 12. Breene, R A, Williams, R M, Hartle, J, et al., Auxological changes in UK survivors of childhood acute lymphoblastic leukaemia treated without cranial irradiation. Br J Cancer 2011; 104: 746-9.