Öz
Objective: To evaluate the relationship between preterm labor and third trimester maternal serum AFP, hCG levels. Materials and Methods: One hundred women who were 27-33 weeks pregnant were enrolled to this study between August 2002 - May 2003 at Zeynep Kamil Women and Children Research and Training Hospital. Fiftyone pregnant women who had the diagnosis of preterm labor were included in the study group and 49 healthy pregnants encompassed the control group. Maternal serum AFP, hCG, maternal age, parity and gestational week were analysed. Results: Maternal age was significantly lower in the preterm labor group compared to the control group(p=0.03) while parity and gestational week were statistically indifferent. Maternal serum AFP and hCG levels had shown no significant difference when compared between two groups (p=0.06 andp=0.170). Conclusions: Third trimester should be considered late in predicting the risk of preterm labor and we have found no relationship between the levels of maternal AFP, hCG and preterm labor in the third , trimester.
Anahtar Kelimeler
Premature Birth Chorionic Gonadotropin alpha-Fetoproteins Pregnancy Trimesters
Kaynakça
- 1. Svigos JM, Robinson JS, Vigneswaran R
- Threatened and actual preterm labor including mode of delivery, inijames DK,Steer PJ.,eds. High Risk Pregnancy. 2nded. WB Sounders Company 1999:999-1015 2. GonikB, Creasy RK. Preterm labor: its diagnos is and management. Am J Obstet Gynecol 1986 Jan;154:3-8 3. Nageotte MP, Casal D , SenyeiAE. Fetal fibronectin in patients at increased risk for premature birth. Am J Obstet Gynecol 1994 Jan;170:20-25 4. Lockwood CJ, Senyei AE, Dische MR, Casal D, Shah KD, Thung SN. Fetal fibronectin in cervical and vaginal secretions as a predictor of preterm delivery. N Engl J Med 1991 Sep;325:669-674 5. Lams JD, Casal D , McGregor JA, Goodwin TM, Kreaden US , Lowensohn R. Fetal fibronectin improves the accuracy of diagnosis of preterm labor. Am J Obstet Gynecol 1995 Jul; 173:141-145 6. Lams fD, Johnson FF, SonekJ, Sachs L, Gebauer C , Samuels P.Cervical competence as a continuum: a study of ultrasonographic cervical length and obstetric performance. Am J Obstet Gynecol 1995 Apr;172:1097-1103 7. Lams JD, Goldenberg RL, Meis PJ, Mercer BM, Moawad A , Das A. The length of the cervix and the risk of spontaneous premature delivery. New Engl J Med 1996 Feb;334:567-572 8. McLean M , Bisits A , Davies J , Walters W, HackshawA, De Voss K. Predicting risk of preterm delivery by second-trimester measurement of maternal plasma corticotropin- releasing hormone and alpha fetoprotein concentrations. Am J Obstet Gynecol 1999;181:207-215 9. Davis OD , Goldenberg RL , Boots L , Hoffman HJ, Copper R, Cutter GR. Elevated levels of midtrimester maternal serum alpha fetoprotein are associated with preterm delivery but not with fetal growth restriction. Am J Obstet Gynecol 1992;167:59.6-601 10. Köse D, Tuğrul S, Saya R, Yıldırım G, Oral Ö. Üçlü tarama testinin olası gebelik komplikasyonlarını belirlemedeki rolü. T Klin Jinekol Obst 2003,13:374- 378 11. Ambrus G, Rao CV. Novel regulation of pregnant human myometrial smooth muscle cell gap junctions by human chorionic gonadotropins. Endocrinology 1994 Dec;135:2772-2779 12. Toth P. Clinical data supporting the importance of vascular LH/HCG receptors of uterine blood vessels.Semin Reprod Med 2001; 19:55-61 13. Kurtzman JT , Spinnato JA , Goldsmith LJ , Zimmerman MJ , Klem M , Lei ZM. Human chorionic gonadotropin exhibits potent inhibition of preterm delivery in a small animal model. Am J Obstet Gynecol 1999:181:853-857 14. Kurtzman JT, Wilson H , Rao V. A proposed role for hCG in clinical obstetrics. Semin Reprod Med 2001:19:63-68 15. Simpson JL, Palomaki GE, Mercer R, Haddow JE , Andersen R , Sibai R. Associations between adverse perinatal outcome and serially obtained second and third trimester maternal serum alpha fetoprotein measurements. Am J Obstet Gynecol 1995;173:1742-1748
Öz
Amaç: Üçüncü trimester serum AFP ve hCG düzeyleri ile preternı eylem arasındaki ilişkiyi araştırmak. Materyal ve Metod: Ağustos 2002 - Mayıs 2003 tarihleri arasında Zeynep Kamil Kadın ve Çocuk Hastalıkları Eğitim ve Araştırma Hastanesi'ne başvuran 27-33 gebelik haftasındaki 100 gebe çalışmaya dahil edildi. Olguların 51 tanesi preterm eylemde iken 49 tanesi kontrol grubu olarak alınmıştır.Olgular yaş, parite, gebelik haftası, maternal serum AFP ve hCG parametreleri açısından karşılaştırıldı. Bulgular: Preterm eylemdeki gebelerde maternal yaş kontrol grubuna göre anlamlı olarak düşük bulunurken(p — 0,03), gebelik haftası ve parite açısından anlamlı fark izlenmedi. Preterm eylem grubu ve kontrol grubunda maternal serum AFP ve hCG arasında anlamlı bir farklılık saptanmadı (p = 0,06vep = 0,170). Sonuç: Üçüncü trimester maternal serum AFP ve hCG düzeylerinin preterm eylem riskinin öngörüsünde değerli olmadığı ve bu dönemin, riski belirlemek için geç bir dönem olduğu kanısına vardık.
Anahtar Kelimeler
Prematüre doğum Koryonik gonadotropin alfa-Fetoproteinler Gebelik trimesterleri
Kaynakça
- 1. Svigos JM, Robinson JS, Vigneswaran R
- Threatened and actual preterm labor including mode of delivery, inijames DK,Steer PJ.,eds. High Risk Pregnancy. 2nded. WB Sounders Company 1999:999-1015 2. GonikB, Creasy RK. Preterm labor: its diagnos is and management. Am J Obstet Gynecol 1986 Jan;154:3-8 3. Nageotte MP, Casal D , SenyeiAE. Fetal fibronectin in patients at increased risk for premature birth. Am J Obstet Gynecol 1994 Jan;170:20-25 4. Lockwood CJ, Senyei AE, Dische MR, Casal D, Shah KD, Thung SN. Fetal fibronectin in cervical and vaginal secretions as a predictor of preterm delivery. N Engl J Med 1991 Sep;325:669-674 5. Lams JD, Casal D , McGregor JA, Goodwin TM, Kreaden US , Lowensohn R. Fetal fibronectin improves the accuracy of diagnosis of preterm labor. Am J Obstet Gynecol 1995 Jul; 173:141-145 6. Lams fD, Johnson FF, SonekJ, Sachs L, Gebauer C , Samuels P.Cervical competence as a continuum: a study of ultrasonographic cervical length and obstetric performance. Am J Obstet Gynecol 1995 Apr;172:1097-1103 7. Lams JD, Goldenberg RL, Meis PJ, Mercer BM, Moawad A , Das A. The length of the cervix and the risk of spontaneous premature delivery. New Engl J Med 1996 Feb;334:567-572 8. McLean M , Bisits A , Davies J , Walters W, HackshawA, De Voss K. Predicting risk of preterm delivery by second-trimester measurement of maternal plasma corticotropin- releasing hormone and alpha fetoprotein concentrations. Am J Obstet Gynecol 1999;181:207-215 9. Davis OD , Goldenberg RL , Boots L , Hoffman HJ, Copper R, Cutter GR. Elevated levels of midtrimester maternal serum alpha fetoprotein are associated with preterm delivery but not with fetal growth restriction. Am J Obstet Gynecol 1992;167:59.6-601 10. Köse D, Tuğrul S, Saya R, Yıldırım G, Oral Ö. Üçlü tarama testinin olası gebelik komplikasyonlarını belirlemedeki rolü. T Klin Jinekol Obst 2003,13:374- 378 11. Ambrus G, Rao CV. Novel regulation of pregnant human myometrial smooth muscle cell gap junctions by human chorionic gonadotropins. Endocrinology 1994 Dec;135:2772-2779 12. Toth P. Clinical data supporting the importance of vascular LH/HCG receptors of uterine blood vessels.Semin Reprod Med 2001; 19:55-61 13. Kurtzman JT , Spinnato JA , Goldsmith LJ , Zimmerman MJ , Klem M , Lei ZM. Human chorionic gonadotropin exhibits potent inhibition of preterm delivery in a small animal model. Am J Obstet Gynecol 1999:181:853-857 14. Kurtzman JT, Wilson H , Rao V. A proposed role for hCG in clinical obstetrics. Semin Reprod Med 2001:19:63-68 15. Simpson JL, Palomaki GE, Mercer R, Haddow JE , Andersen R , Sibai R. Associations between adverse perinatal outcome and serially obtained second and third trimester maternal serum alpha fetoprotein measurements. Am J Obstet Gynecol 1995;173:1742-1748
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Bölüm | Makaleler |
| Yazarlar | |
| Yayımlanma Tarihi | 1 Nisan 2004 |
| Yayımlandığı Sayı | Yıl 2004 Cilt: 35 Sayı: 3 |