Evaluation of trombophilia in habitual abortion cases

Yıl 2009, Cilt: 40 Sayı: 3, 105 - 109, 01.04.2009

İtibar Eminli Mustafa Kara Ercan Yılmaz Tufan Öge Cüneyt Evrüke

Öz

Objective: We aimed to research the effect of the thrombophilia factors in the of habitual abortion. cases Material and Methods: The patients who participated to the Çukurova University Faculty of Medicine, Department of Gynecology and Obstetrics between in December 2004 to March 2006 with the diagnosis of habitual abortion were included to the study. The number of the patient group was 66 and the control group was 74. There were 74 healthy women in the control group, at the same age,without the story of habitual abortion and systemic disease and without familial and individual history of thrombosis and delivered by vaginal way or by caeseraean without developing any obstetric complication. Results: The average age of the patient group was 29.3 ± 5.4, the control group was 27.4 ± 5.2 years and the difference between the two groups were not statistically significant. The difference of the Protein C and Antitrombin III values between habitual abortion and control groups was found significant,while the differences in terms of values of Factor VLeiden, Protrombin G20210A, and MTHFR C677 T mutations and Protein S values was not statistically significant at the end of the study. Conclusion: Maternal thrombophilias (Factor V Leiden,Protrombin G20210A, MTHFR C677 T mutation, Protein C, Protein S and AT III deficiencies) is important in terms of obstetric way. The majority of the studies have shown that a tight link between factor V Leiden and vascular placental insufficiency in the patients with habitual abortion. Finally, in the patient group Antitrombin III and Protein C levels were found lower than the control group and this difference was not statistically significant. There was not a significant difference between patient and control groups in terms of Protein S, Factor V Leiden,Protrombin G20210A and MTHFR C677 T mutations.

Anahtar Kelimeler

Abortion, Habitual, Factor V leiden, Antithrombin III, Age Distribution, Protein C, Protein S, Prothrombin, Evaluation Studies

Habitüel abortuslu hastalarda trombofilinin araştırılması

Öz

Amaç: Bu çalışmada tekrarlayan gebelik kayıpları olan hastalarda trombofıli faktörlerinin etkisini araştırmayı amaçladık Materyal ve Metod: Çalışmaya Aralık 2004- Mart 2006 tarihleri arasında Çukurova Üniversitesi Tıp Fakültesi Kadın Hastalıkları ve Doğum Anabilim Dalına habitüel abortus tanısı ile başvuran hastalar dahil edilmiştir.Hasta grubu 66, kontrol grubu 74 kişiydi.Kontrol grubunda aynı yaş grubunda, habitüel abortus öyküsü ve sistemik hastalığı olmayan, tromboz açısından bireysel ve ailesel öyküsü olmayan, herhangi bir obstetrik komplikasyon gelişmeden vaginal yolla veya sezaryenle doğum yapmış sağlıklı 74 kadın mevcuttu. Sonuç: Hasta grubunun yaş ortalaması 29,3±5.4, kontrol grubunun yaş ortalaması ise 27.4±5,2 olup iki grup arasındaki yaş farkı istatiksel olarak anlamlı değildi.Çalışma sonucunda habitüel abortus ve kontrol grupları arasında Protein C ve Antitrombin III (AT III) değerleri açısından anlamlı fark bulunurken, Faktör V Leiden, Protrombin G20210A, MTHFR C677 T mutasyonları ve Protein S değeri arasındaki fark istatiksel olarak anlamsız bulunmuştur. Tartışma: Maternal trombofililer (Faktör V Leiden,Protrombin G20210A, MTHFR C677 T mutasyonu, Protein C, Protein S ve AT III eksiklikleri) obstetrik açıdan önemlidir. Habitüel abortuslu hastalarda çalışmaların çoğu, Faktör V Leiden ve vasküler plasenta! yetmezlik arasında sıkı bir bağ olduğunu göstermektedir. Sonuç olarak, Antitrombin III ve Protein C hasta grubunda daha düşük düzeylerde bulunmuş ve bu fark istatiksel olarak anlamlı kabul edilmiştir. Protein S, Faktör VLeiden, Protrombin G20210A ve MTHFR C677T mutasyonları açısından hasta ve kontrol grubu arasında anlamlı bir fark bulunamamıştır.

Anahtar Kelimeler

Düşük, tekrarlayan, Faktör V leiden, Antitrombin III, Yaş dağılımı, Protein C, Protein S, Protrombin, Değerlendirme çalışmaları

Kaynakça

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