Köpek ve Kedilerde Böbrek Hastalıklarında Biyobelirteçlerin Klinik Kullanımı

Tuğrul Kırkulak; Gülten Emek Tuna; Sezai Arslan; Şebnem Canikli Engin

doi:10.35229/jaes.1830234

EN TR

Clinical Utility of Biomarkers in Canine and Feline Kidney Diseases

Abstract

Urinary system diseases are quite common in cats and dogs. Due to nutritional deficiencies and delayed presentation of patients to veterinary clinics, the disease progresses to the kidneys, becoming more complicated and associated with a poor prognosis in advanced stages. Kidney diseases are often subclinical and can only be diagnosed when clinical signs of uremia appear or in the later stages of kidney disease. Serum urea and creatinine concentrations have traditionally been used to diagnose kidney disease. However, even if 25% of nephrons have normal filtration capacity, these parameters may fall within the reference ranges. Therefore, they may be insufficient for early detection of renal insufficiency. Furthermore, serum urea and creatinine concentrations alone are insufficient for distinguishing between prerenal, renal, and postrenal azotemia, determining patient prognosis, or differentiating acute kidney injury from chronic renal failure. Therefore, new and effective biomarkers are needed to diagnose kidney damage early in cats and dogs, slow or completely eliminate disease progression, ensure timely therapeutic intervention, and improve life expectancy and quality of life. This study provides comprehensive information on biomarkers frequently used in the diagnosis and management of kidney diseases in cats and dogs, as well as those that are likely to be used routinely in the future.

Keywords

Biomarkers, Kidney failure, Cat, Dog, Urinary tract.

Köpek ve Kedilerde Böbrek Hastalıklarında Biyobelirteçlerin Klinik Kullanımı

Abstract

Kedi ve köpeklerde üriner sistem hastalıkları oldukça sık görülmektedir. Gerek beslenme hataları, gerekse hastaların veteriner kliniklerine geç götürülmeleri nedeniyle hastalık böbreklere ulaşarak komplike bir hal almakta ve ileri aşamalarda da kötü prognozla ilişkilendirilmektedir. Böbrek hastalıkları genellikle subklinik seyreder ve üreminin klinik belirtilerinin ortaya çıktığı dönemde ya da böbrek hastalığının ileri safhasında teşhis edilebilir. Böbrek hastalıklarının teşhisinde geleneksel olarak serum üre ve kreatinin konsantrasyonları kullanılmaktadır. Ancak, nefronların % 25’i normal filtrasyon kapasitesine sahip olsa bile bu parametreler referans aralıkları içerisinde olabilir. Bu nedenle de renal yetmezliklerin erken dönemde belirlenmesinde yetersiz kalabilirler. Ayrıca, serum üre ve kreatinin konsantrasyonları prerenal, renal ve postrenal azoteminin birbirinden ayırt edilmesinde, hastanın prognozunun saptanmasında, akut böbrek hasarının kronik böbrek yetmezliğinden ayırt edilmesinde de tek başlarına faydalı değildirler. Bu nedenle kedi ve köpeklerde böbrek hasarını erken teşhis edip, hastalığın ilerleyişini yavaşlatmak ya da tamamen ortadan kaldırmak, terapötik müdahalenin zamanında gerçekleşmesini sağlayıp yaşam süresi ve kalitesini arttırmak için yeni ve etkin biyobeliteçlere ihtiyaç duyulmaktadır. Bu çalışmada kedi ve köpeklerde böbrek hastalıklarının tanısında ve hastalık sürecinin yönetilmesinde sıklıkla kullanılan ve gelecekte rutinde kullanılması muhtemel biyobelirteçler hakkında kapsamlı bilgilere yer verilmiştir.

Keywords

Biyobelirteçler, Böbrek yetmezliği, Kedi, Köpek, Üriner kanal

Ethical Statement

The study adhered to ethical rules and observed scientific principles. Because the research was based on document analysis and descriptive analysis, an ethics committee decision was not required.

References

Bayendur, S.H., & Acar, A. (2026). Assessment of kidney injury biomarkers in cats with obstructive and non‐obstructive lower urinary tract disease. Veterinary Record, e1-e3. https://doi.org/10.1002/vetr.70230
Brown, S., Elliott, J., Francey, T., Polzin, D., & Vaden, S. (2013). Consensus recommendations for standard therapy of glomerular disease in dogs. Journal of Veterinary Internal Medicine, 27, S27- S43. https://doi.org/10.1111/jvim.12230
Burt, D., Crowell, S.J., Ackley, D.C., Magee, T.V., & Aubrecht, J. (2014). Application of emerging biomarkers of acute kidney injury in development of kidney-sparing polypeptide-based antibiotics. Drug and Chemical Toxicology, 37(2), 204-212. https://doi.org/10.3109/01480545.2013.834360
Chen, H., Avital, Y., Peterson, S., Ouyang, Z., Yerramilli, M., Aroch, I., & Segev, G. (2024). Urinary cystatin B as a marker of acute kidney injury in cats. The Veterinary Journal, 308, 106262. https://doi.org/10.1016/j.tvjl.2024.106262
De Oliveira Paes-Leme, F., de Souza, E.M., Ceregatti, M.G., Campos, M.T.G., de Melo, P.D.V., & da Costa-Val, A.P. (2022). Cystatin C assay validation using the immunoturbidimetric method to evaluate the renal function of healthy dogs and dogs with acute renal injury. Veterinary World, 15(6), 1595. https://doi.org/10.14202/vetworld.2022.1595- 1600
Erfidan, M.A. (2024). Geriatrik Köpeklerde Serum Kreatinin, Sistatin C, Simetrik Dimetilarginin ve Rezistif İndeks Parametrelerinin Karşılaştırılması. Doktora Tezi, Afyon Kocatepe Üniversitesi, Sağlık Bilimleri Enstitüsü, Afyonkarahisar, Türkiye, 90s.
Erkoç, E., & Civelek, T. (2025). Comparison of Ultrasonographic and Laboratory Findings in Feline Lower Urinary Tract Disease. Kocatepe Veterinary Journal, 18(2), 153-163.
Ghys, L.F., Meyer, E., Paepe, D., Delanghe, J., & Daminet, S. (2014). Analytical validation of a human particle‐enhanced nephelometric assay for cystatin C measurement in feline serum and urine. Veterinary Clinical Pathology, 43(2), 226-234. https://doi.org/10.1111/vcp.12144
Gordin, E., Gordin, D., Viitanen, S., Szlosek, D., Coyne, M., Farace, G., ..., & Spillmann, T. (2021). Urinary clusterin and cystatin B as biomarkers of tubular injury in dogs following envenomation by the European adder. Research in Veterinary Science, 134, 12-18. https://doi.org/10.1016/j.rvsc.2020.11.019
Grauer, G.F. (2011). Proteinuria: measurement and interpretation. Topics in Companion Animal Medicine, 26(3), 121-127. https://doi.org/10.1053/j.tcam.2011.04.002

Güneş, V. (2026). Serum clusterin as a sensitive biomarker for kidney disease in cats: a comparative evaluation in acute renal failure and chronic kidney disease. 9th International Selçuk Scientific Research Congress, Konya, Türkiye.
Hall, J.A., Yerramilli, M.V.S.N., Obare, E., Yerramilli, M., & Jewell, D.E. (2014). Comparison of serum concentrations of symmetric dimethylarginine and creatinine as kidney function biomarkers in cats with chronic kidney disease. Journal of Veterinary Internal Medicine, 28(6), 1676-1683. https://doi.org/10.1111/jvim.12445
Hokamp, J.A., & Nabity, M.B. (2016). Renal biomarkers in domestic species. Veterinary Clinical Pathology, 45(1), 28-56. https://doi.org/10.1111/vcp.12333
Hrovat, A., Schoeman, J.P., de Laat, B., Meyer, E., Smets, P., Goddard, A., ..., & Daminet, S. (2013). Evaluation of snake envenomation- induced renal dysfunction in dogs using early urinary biomarkers of nephrotoxicity. The Veterinary Journal, 198(1), 239-244. https://doi.org/10.1016/j.tvjl.2013.06.030
Jepson, R.E., Syme, H.M., Markwell, P., Miyazaki, M., Yamashita, T., & Elliott, J. (2010). Measurement of urinary cauxin in geriatric cats with variable plasma creatinine concentrations and proteinuria and evaluation of urine cauxin-to- creatinine concentration ratio as a predictor of developing azotemia. American Journal of Veterinary Research, 71(8), 982-987. https://doi.org/10.2460/ajvr.71.8.982
Kaseda, R., Iino, N., Hosojima, M., Takeda, T., Hosaka, K., Kobayashi, A., ..., & Saito, A. (2007). Megalin-mediated endocytosis of cystatin C in proximal tubule cells. Biochemical and Biophysical Research Communications, 357(4), 1130-1134. https://doi.org/10.1016/j.bbrc.2007.04.072
Kielstein, J.T., Salpeter, S.R., Bode-Boeger, S.M., Cooke, J.P., & Fliser, D. (2006). Symmetric dimethylarginine (SDMA) as endogenous marker of renal function-a meta-analysis. Nephrology Dialysis Transplantation, 21(9), 2446-2451. https://doi.org/10.1093/ndt/gfl292
Kongtasai, T. (2024). Renal biomarkers in cats: A review of the current status in chronic kidney disease. Journal of Japanese Assocıatıon of Veterınary Nephrology and Urology, 15(1), 23-40. https://doi.org/10.24678/javnu.15.1_23
Kongtasai, T., Meyer, E., Paepe, D., Marynissen, S., Smets, P., Mortier, F., ..., & Daminet, S. (2021). Liver‐type fatty acid‐binding protein and neutrophil gelatinase‐associated lipocalin in cats with chronic kidney disease and hyperthyroidism Journal of Veterinary Internal Medicine, 35(3), 1376-1388. https://doi.org/10.1111/jvim.16074
Kovarikova, S. (2015). Urinary biomarkers of renal function in dogs and cats: a review. Veterinární Medicína, 60(11), 589-602. https://doi.org/10.17221/8527
Köse, S.İ., & Maden, M. (2015). Üriner Biyobelirteçler. Turkiye Klinikleri Journal of Veterinary Sciences, 6(1), 7-18. https://doi.org/10.5336/vetsci.2013- 34080
Lefebvre, H.P. (2011). Renal function testing. Nephrology and Urology of Small Animals, 91-96. https://doi.org/10.1002/9781118785546.ch14
Linnetz, E.H., & Graves, T.K. (2010). Glomerular filtration rate in general small animal practice. Compendium: Continuing Education for Veterinarians, 32(10), E1-E5.
Loane, S.C., Thomson, J.M., Williams, T.L., & McCallum, K.E. (2022). Evaluation of symmetric dimethylarginine in cats with acute kidney injury and chronic kidney disease. Journal of Veterinary Internal Medicine, 36(5), 1669- 1676. https://doi.org/10.1111/jvim.16497
Maddens, B.E., Daminet, S., Demeyere, K., Demon, D., Smets, P., & Meyer, E. (2010). Validation of immunoassays for the candidate renal markers C- reactive protein, immunoglobulin G, thromboxane B2 and retinol binding protein in canine urine. Veterinary Immunology and Immunopathology, 134(3-4), 259-264. https://doi.org/10.1016/j.vetimm.2009.09.003
Mobasheri, A., & Cassidy, J.P. (2010). Biomarkers in veterinary medicine: Towards targeted, individualised therapies for companion animals. The Veterinary Journal, 185(1), 1-3. https://doi.org/10.1016/j.tvjl.2010.04.003.
Nabity, M.B., Lees, G.E., Boggess, M.M., Yerramilli, M., Obare, E., Yerramilli, M., ..., & Relford, R. (2015). Symmetric dimethylarginine assay validation, stability, and evaluation as a marker for the early detection of chronic kidney disease in dogs. Journal of Veterinary Internal Medicine, 29(4), 1036-1044. https://doi.org/10.1111/jvim.12835
Nivy, R., Avital, Y., Aroch, I., & Segev, G. (2017). Utility of urinary alkaline phosphatase and γ-glutamyl transpeptidase in diagnosing acute kidney injury in dogs. The Veterinary Journal, 220, 43-47. https://doi.org/10.1016/j.tvjl.2016.12.010
Özdemir, H. (2025). Urolitiazis’li Kedilerde Böbrek Hasarının Araştırılması. Yüksek Lisans Tezi, Burdur Mehmet Akif Ersoy Üniversitesi, Sağlık Bilimleri Enstitüsü, Burdur, Türkiye, 102s.
Peake, M., & Whiting, M. (2006). Measurement of serum creatinine-current status and future goals. Clinical Biochemist Reviews, 27(4), 173.
Pereira, A.F., Jota Baptista, C., Faustino-Rocha, A., Oliveira, P.A., & Coelho, A.C. (2025). Renal biomarkers in companion animals-a review. Animals, 15(6), 818. https://doi.org/10.3390/ani15060818
Pozzoli, S., Simonini, M., & Manunta, P. (2018). Predicting acute kidney injury: current status and future challenges. Journal of Nephrology, 31(2), 209-223. https://doi.org/10.1007/s40620-017- 0416-8
Raila, J., Brunnberg, L., Schweigert, F.J., & Kohn, B. (2010). Influence of kidney function on urinary excretion of albumin and retinol-binding protein in dogs with naturally occurring renal disease. American Journal of Veterinary Research, 71(11), 1387-1394. https://doi.org/10.2460/ajvr.71.11.1387
Rentko, V., Nabity, M., Yerramilli, M., Obare, E., Aguiar, J., & Relford, R. (2013). P-7 Determınatıon of Serum Symmetrıc Dımethy- Largınıne Reference Lımıt in Clınıcally Healthy Dogs. Journal of Veterinary Internal Medicine, 27(3), 750.
Sargent, H.J., Jepson, R.E., Chang, Y.M., Biourge, V.C., Bijsmans, E.S., & Elliott, J. (2019). Fibroblast growth factor 23 and symmetric dimethylarginine concentrations in geriatric cats. Journal of Veterinary Internal Medicine, 33(6), 2657-2664. https://doi.org/10.1111/jvim.15590
Scheemaeker, S., Meyer, E., Schoeman, J.P., Defauw, P., Duchateau, L., & Daminet, S. (2020). Urinary neutrophil gelatinase-associated lipocalin as an early biomarker for acute kidney injury in dogs. The Veterinary Journal, 255, 105423. https://doi.org/10.1016/j.tvjl.2019.105423
Segev, G., Kass, P.H., Francey, T., & Cowgill, L.D. (2008). A novel clinical scoring system for outcome prediction in dogs with acute kidney injury managed by hemodialysis. Journal of Veterinary Internal Medicine, 22(2), 301-308. https://doi.org/10.1111/j.1939-1676.2008.0063.x
Smets, P.M., Meyer, E., Maddens, B., Duchateau, L., & Daminet, S. (2010). Effect of sampling method and storage conditions on albumin, retinol- binding protein, and N-acetyl-β-D- glucosaminidase concentrations in canine urine samples. Journal of Veterinary Diagnostic Investigation, 22(6), 896-902. https://doi.org/10.1177/104063871002200607
Thomas, A.A., Demirjian, S., Lane, B.R., Simmons, M.N., Goldfarb, D.A., Subramanian, V.S., & Campbell, S.C. (2011). Acute kidney injury: novel biomarkers and potential utility for patient care in urology. Urology, 77(1), 5-11. https://doi.org/10.1016/j.urology.2010.05.004
Urbschat, A., Obermüller, N., & Haferkamp, A. (2011). Biomarkers of kidney injury. Biomarkers, 16(sup1), S22-S30. https://doi.org/10.3109/1354750X.2011.587129
Ülkü, E., & Yıldız, R. (2020). Hayvanlarda Böbrek Hastalıklarının Erken Teşhisinde Biyobelirteç Olarak Proteomiklerin Önemi. Türkiye Klinikleri Journal of Veterinary Sciences, 11(1). https://doi.org/10.5336/vetsci.2019-72335
Williams, T.L., Dillon, H., Elliott, J., Syme, H.M., & Archer, J. (2016). Serum cystatin C concentrations in cats with hyperthyroidism and chronic kidney disease. Journal of Veterinary Internal Medicine, 30(4), 1083-1089. https://doi.org/10.1111/jvim.13956
Yerramilli, M., Obare, E., Jewell, D.E., & Hall, J.A. (2014). Symmetric Dimethylarginine (SDMA) Increases Earlıer Than Serum Creatınıne in Dogs Wıth Chronic Kidney Disease (CKD). NU-42. Journal of Veterinary Internal Medicine, 28(3), 1084-1085.
Yılmaz, Z., Algan, D., Varlik, T., & Tunbul, Y. (2025). Evaluation of Gastrin, Amylase, Homocysteine, and Cystatin C as Indicators of Renal Failure Severity in Dogs. Türk Veteriner Cerrahi Dergisi, 4(1), 8-12.
Zhang, W.R., & Parikh, C.R. (2019). Biomarkers of acute and chronic kidney disease. Annual Review of Physiology, 81(1), 309-333. https://doi.org/10.1146/annurev-physiol-020518- 114605
Zhou, X., Ma, B., Lin, Z., Qu, Z., Huo, Y., Wang, J., & Li, B. (2014). Evaluation of the usefulness of novel biomarkers for drug-induced acute kidney injury in beagle dogs. Toxicology and Applied Pharmacology, 280(1), 30-35. https://doi.org/10.1016/j.taap.2014.07.002

Details

Primary Language

Turkish

Subjects

Veterinary Urology, Veterinary Sciences (Other)

Journal Section

Review

Authors

Tuğrul Kırkulak ^*
0009-0009-0239-166X
Türkiye

Gülten Emek Tuna
0000-0002-9729-8813
Türkiye

Sezai Arslan
0000-0001-9537-6024
Türkiye

Şebnem Canikli Engin
0009-0007-7528-0333
Türkiye

Publication Date

May 21, 2026

Submission Date

November 25, 2025

Acceptance Date

April 3, 2026

Published in Issue

Year 2026 Number: 2026

DOI

https://doi.org/10.35229/jaes.1830234

IZ

https://izlik.org/JA36AR86KG

APA

Kırkulak, T., Tuna, G. E., Arslan, S., & Canikli Engin, Ş. (2026). Köpek ve Kedilerde Böbrek Hastalıklarında Biyobelirteçlerin Klinik Kullanımı. Journal of Anatolian Environmental and Animal Sciences, 2026. https://doi.org/10.35229/jaes.1830234

AMA

1.Kırkulak T, Tuna GE, Arslan S, Canikli Engin Ş. Köpek ve Kedilerde Böbrek Hastalıklarında Biyobelirteçlerin Klinik Kullanımı. JAES. 2026;(2026). doi:10.35229/jaes.1830234

Chicago

Kırkulak, Tuğrul, Gülten Emek Tuna, Sezai Arslan, and Şebnem Canikli Engin. 2026. “Köpek Ve Kedilerde Böbrek Hastalıklarında Biyobelirteçlerin Klinik Kullanımı”. Journal of Anatolian Environmental and Animal Sciences, nos. 2026. https://doi.org/10.35229/jaes.1830234.

EndNote

Kırkulak T, Tuna GE, Arslan S, Canikli Engin Ş (May 1, 2026) Köpek ve Kedilerde Böbrek Hastalıklarında Biyobelirteçlerin Klinik Kullanımı. Journal of Anatolian Environmental and Animal Sciences 2026

IEEE

[1]T. Kırkulak, G. E. Tuna, S. Arslan, and Ş. Canikli Engin, “Köpek ve Kedilerde Böbrek Hastalıklarında Biyobelirteçlerin Klinik Kullanımı”, JAES, no. 2026, May 2026, doi: 10.35229/jaes.1830234.

ISNAD

Kırkulak, Tuğrul - Tuna, Gülten Emek - Arslan, Sezai - Canikli Engin, Şebnem. “Köpek Ve Kedilerde Böbrek Hastalıklarında Biyobelirteçlerin Klinik Kullanımı”. Journal of Anatolian Environmental and Animal Sciences. 2026 (May 1, 2026). https://doi.org/10.35229/jaes.1830234.

JAMA

1.Kırkulak T, Tuna GE, Arslan S, Canikli Engin Ş. Köpek ve Kedilerde Böbrek Hastalıklarında Biyobelirteçlerin Klinik Kullanımı. JAES. 2026. doi:10.35229/jaes.1830234.

MLA

Kırkulak, Tuğrul, et al. “Köpek Ve Kedilerde Böbrek Hastalıklarında Biyobelirteçlerin Klinik Kullanımı”. Journal of Anatolian Environmental and Animal Sciences, no. 2026, May 2026, doi:10.35229/jaes.1830234.

Vancouver

1.Tuğrul Kırkulak, Gülten Emek Tuna, Sezai Arslan, Şebnem Canikli Engin. Köpek ve Kedilerde Böbrek Hastalıklarında Biyobelirteçlerin Klinik Kullanımı. JAES. 2026 May 1;(2026). doi:10.35229/jaes.1830234

EBSCOHost Scilit CABI

JAES/AAS-Journal of Anatolian Environmental and Animal Sciences/Anatolian Academic Sciences&Anadolu Çevre ve Hayvancılık Dergisi/Anadolu Akademik Bilimler-AÇEH/AAS

Clinical Utility of Biomarkers in Canine and Feline Kidney Diseases

Abstract

Keywords

Köpek ve Kedilerde Böbrek Hastalıklarında Biyobelirteçlerin Klinik Kullanımı

Abstract

Keywords

Ethical Statement

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

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