SCUBE1 and Irisin Relation in Bladder Cancer

Yıl 2023, Cilt: 2 Sayı: 1, 26 - 30, 30.03.2023

Diler Us Altay

Öz

Bladder Cancer (BC) is a urogenital system disease with a frequency of approximately 11.000 new cases. The major risk factors of BC are smoking and exposure to industrial carcinogens. The diagnosis and monitoring of BC largely consist of invasive tests involving periodic cystoscopy. This method is known as the gold standard although this is a trustworthy method the procedure is highly disturbing for the cancer patient and causes comorbidity. That’s why; non-invasive diagnostic methods continue to be researched. Signal Peptide CUB Epidermal Growth Factor 1 Containing Protein (SCUBE1) is a member of the SCUBE family. SCUBE1 is often closely associated with pathological conditions such as thrombus, atherosclerotic plaque, inflammation, and hypoxia-related disorders. Many recent studies have focused on the expression and function of the SCUBE family in cancer. Studies of the SCUBE family have demonstrated the potential to develop as a diagnostic or prognostic biomarker in cancer. Irisin is an adipocytokine produced by proteolytic cleavage of the fibronectin type III domain-containing protein 5 (FNDC5). There are many studies examining the relationship between irisin and cancer. Although SCUBE1 and irisin have been evaluated as early diagnosis biomarkers of bladder cancer in many studies, no study evaluating the parameters together has been found. In the future, multicenter studies evaluating SCUBE1 and irisin parameters together are needed for the early diagnosis of bladder cancer in people who smoke and are exposed to various chemicals.

Anahtar Kelimeler

SCUBE1, Irisin, bladder cancer

Mesane Kanserinde SCUBE1 ve İrisin İlişkisi

Öz

Mesane Kanseri (MK) yaklaşık 11,000 yeni vaka sıklığına sahip ürogenital sistem hastalığıdır. Mesane kanserinin başlıca risk faktörleri sigara içmek ve endüstriyel kanserojenlere maruz kalmaktır. MK'nın teşhisi ve izlenmesi büyük ölçüde periyodik sistoskopiyi içeren invaziv testlerden oluşur. Bu yöntem altın standart olarak bilinir, güvenilir bir yöntem olmasına rağmen işlem hasta için oldukça rahatsız edicidir ve komorbiditeye neden olur. Bu nedenle non-invaziv tanı yöntemleri araştırılmaya devam etmektedir. Sinyal Peptit CUB Epidermal Büyüme Faktörü 1 İçeren Protein (SCUBE1), SCUBE ailesinin bir üyesidir. SCUBE1 genellikle trombüs, aterosklerotik plak, inflamasyon ve hipoksi ile ilişkili bozukluklar gibi patolojik durumlarla yakından ilişkilidir. Son zamanlarda yapılan birçok çalışma da SCUBE ailesinin kanserdeki ekspresyonu ve işlevine odaklanılmaktadır. SCUBE ailesi ile ilgili yapılan çalışmalar, kanserde teşhis veya prognostik bir biyobelirteç olarak gelişme potansiyeli olduğunu göstermiştir. İrisin, Fibronektin Tip III Domainini İçeren 5. proteinin (FNDC5) proteolitik bölünmesiyle üretilen bir adipomiyokindir. İrisin ve kanser arasındaki ilişkiyi inceleyen birçok araştırma vardır. SCUBE1 ve irisin, birçok çalışmada mesane kanseri için erken tanı biyobelirteci olarak değerlendirilmesine rağmen parametreleri birlikte değerlendiren bir çalışmaya rastlanılmamıştır. Gelecekte, sigara içen ve çeşitli kimyasalara maruz kalan kişilerde erken mesane kanseri tanısı için SCUBE1 ve irisin parametrelerini birlikte değerlendiren çok merkezli çalışmalara ihtiyaç duyulmaktadır.

Anahtar Kelimeler

scube1, mesane kanseri, irisin, SCUBE1, Irisin

Kaynakça

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