Vitamin B12 Düzeyleri ile Kardiyovasküler Hastalık Risk Gruplarının Karşılaştırılması

Yıl 2025, Cilt: 4 Sayı: 3, 73 - 79, 30.09.2025

Mustafa Güner , Elif Ateş

https://doi.org/10.59518/farabimedj.1667573

Öz

Vitamin B12 suda çözünen ve çeşitli metabolik süreçlerin yürütülmesinde kullanılan bir vitamindir. Aneminin önlenmesinde, sinir hüclerinin fonksiyonlarını sağlıklı sürdürmesinde ve DNA sentezinde önemli görevleri vardır. Ayrıca B12 vitamini homosistein metabolizmasında kofaktör olarak bulunur. Homosistein endotelde bir dizi değişikliklere sebep olup; kardiyovasküler hastalıklarla (KVH) ilişkilendirilmiştir. KVH’lara bağlı ölümler ülkemizde hala tüm ölümler içinde birinci sırada bulunmaktadır Vitamin B12 eksikliği ile kardiyovasküler hastalık riski arasındaki ilişki akademik alanda henüz netlik kazanmamıştır. Bu retrospektif kesitsel çalışmada kişilerin vitamin B12 düzeyleri ile KVH risk gruplarını karşılaştırmayı amaçladık. Çalışmaya her risk grubunda 32 kişi olacak şekilde toplam 128 kişi alındı. SCORE (Sistemic Coronary Risk Evaluation) risk modeli kullanılarak dört risk grubunun vitamin B12 düzeylerini karşılaştırdık. KVH risk grupları ile vitamin B12 düzeyleri karşılaştırıldığında aradaki fark istatistiksel olarak anlamlı bulunmadı (p=0.209) ve aralarında kolerasyon saptanmadı (p>0.05). Kardiyovasküler hastalıklar günümüzde hala önemli bir halk sağlığı sorunu olduğundan, yüksek riskli bireylerin belirlenmesinde kolaylık ve fayda sağlayacak ek parametreler üzerinde çalışılması gerekmektedir.

Anahtar Kelimeler

Kalp hastalıkları , Risk değerlendirmesi , Vitamin B12

Proje Numarası

24237859-758

Comparison of Vitamin B12 Levels and Cardiovascular Disease Risk Groups

Öz

Vitamin B12 is a water-soluble vitamin involved in various metabolic processes. It plays a crucial role in the prevention of anemia, the maintenance of healthy neuronal function, and DNA synthesis. Moreover, vitamin B12 acts as a cofactor in homocysteine metabolism. Elevated homocysteine levels have been associated with a range of endothelial alterations and have been linked to cardiovascular diseases (CVD). In Turkey, CVD-related mortality remains the leading cause of death. However, the relationship between vitamin B12 deficiency and the risk of CVD has not yet been clearly established in the academic literature. In this retrospective cross-sectional study, we aimed to compare individuals' vitamin B12 levels across different CVD risk groups. A total of 128 participants were included, with 32 individuals in each risk group. Using the SCORE (Systemic Coronary Risk Evaluation) risk model, we compared vitamin B12 levels across four CVD risk categories. The differences in vitamin B12 levels among the CVD risk groups were not statistically significant (p=0.209), and no correlation was found (p>0.05). Given that cardiovascular diseases continue to pose a major public health concern, further studies are needed to identify additional parameters that may assist in the identification of high-risk individuals.

Anahtar Kelimeler

Heart diseases , Risk assessment , Vitamin B12

Etik Beyan

For this research, ethics committee approval was obtained from the Ethics Committee of the Faculty of Medicine, Karadeniz Technical University, dated September 7, 2021, with the reference number 24237859-758.

Proje Numarası

24237859-758

Teşekkür

We would like to express our sincere gratitude to Prof. Dr. Turan Set, Head of the Department at Karadeniz Technical University, for his invaluable guidance, support, and contributions throughout this study.

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