The corelation between anti Mullerian Hormone levels and size of endometrioma

Yıl 2008, Cilt 39, Sayı 1, 17 - 19, 01.02.2008

Namık Kemal DURU Seyit Temel CEYHAN İbrahim ALANBAY Uğur KESKİN Murat MUHCU İskender BAŞER

Öz

Objective: To show whether there is a corelation between the size of endometrioma and AMH (Anti- Müllerian Hormon) levels in patients who undergo unilateral or bilateral endometrioma stripping. Material and Method: 47 patients with endometrioma of 45 mm or larger were chosen. Endometrioma was unilateral in 33 patients while bilateral in 14. Blood tests for AMH, FSH and estradiol were applied on the 3rd day of the menstruation period before and 1 month after the operation. Results : There was no corelation between levels ofpreoperative and postoperative AMH levels and size of endometrioma in unilateral or bilateral cases. Conclusion: The results of this study indicate that the size of endometrioma does not have a damaging effect on the follicle reserve. In short follow-ups, endometrioma stripping does not damage the healthy ovarian tissue secreting AMH and there is no corelation between AMH levels and the size of endometrioma.

Anahtar Kelimeler

Anti-Mullerian Hormone, Endometrium, Endometriosis, Follicle Stimulating Hormone, Estradiol

Ovarian endometrioma boyutu ve anti müllerin hormon düzeylerinin korelasyonu

Öz

Amaç: Amaç, unilateral veya bilateral endometrioma stripping uygulanan hastalarda endometrioma boyutu ile AMH seviyeleri arasında korelasyon olup olmadığının gösterilmesi. Gereç ve Yöntem: Endometrioma boyutu 45 mm ve daha büyük olan 47 hasta seçildi. Bu vakalardan 33 vakada endometrioma unilateral, 14 hastada bilateraldi. Hastalardan operasyon öncesi ve operasyondan 1 ay sonrasında menstruel siklusun üçüncü gününde AMH, FSHve Estradiol için kan alındı. Bulgular: Preoperatif ve postoperatif AMH düzeyleri hem unilateral hem bilateral endometriomalı hastalarda endometrioma boyutu ile korelasyon göstermemektedir. Sonuç: Bu çalışmanın sonuçları endometrioma boyutunun folliküler havuz üzerinde hasar verici etkiye sahip olmadığını, kısa süreli izlemde ise, endometrioma stripping yönteminin AMH sekrete eden sağlıklı doku üzerinde hasar oluşturmadığını ve kist boyutu ile AMH seviyeleri arasında korelasyon gözlenmediğini ortaya koymuştur.

Anahtar Kelimeler

Anti-Mullerian Hormon, Endometriyum, Endometriyoz, Folikül uyarıcı hormon, Östradiol

Kaynakça

• 1. Garry R. Laparoscopic excision ofendometriosis: the treatment of choice? Br J Obstet Gyneacol 1997,104:513-5.2. 2. Nisolle M, Donnez J. Peritoneal endometriosis, ovarian endometriosis and adenomyotic nodules of the rectovaginal septum are three distinct entities
• Fertil Steril 1997;68:585-96
• 3. Loh FH, Tan AI, Kumar J, Ng SC. Ovarian response after laparoscopic ovarian cystectomy for endometriotic cysts in 132 monitored cycles.Fertil Steril 1999,72:316-21
• 4. Jenny A Visser, Frank H de Jong, Joop S E Lavenl and Axel P N Themmen. Anti-Mullerian hormone: a new marker for ovarian function
• Reproduction, 2006, 131, 1-9
• 5. Annemarie G.M. G.J.Mulders, Joop S.E.Laven, Marinus J.C.Eijkemans, Frank H.de Jong, Axel P.N.Themmen and Bart C.J.M.Fauser. Changes in anti-Mullerian hormone serum concentrations over time suggest delayed ovarian ageing in normogonadotrophic anovulatory infertility Human Reproduction, 2004, 19(9), 2036-2042
• 6. Garciee valescoi fertil steril 2004 7. Donnez J, Nisolle M, Gillet N, Smets M, Bassil S, Casanas-Roux F. Large ovarian endometriomas
• Hum Reprod 1996,11, 641-646
• 8. Hemmings R, Bissonnette F, Bouzayen R. Results of laparoscopic treatments of ovarian endometriomas: laparoscopic ovarian fenestration and coagulation. Fertil Steril 1998, 70, 527-529
• 9. Seifer DB, MacLaughlin DT, Christian BP, Feng B and Shelden RM, Early follicular serum mu'llerian-inhbiting substance levels are associated with ovarian response during assisted reproductive technology cycles. Fertil Steril, 2002, 77, 468-471
• 10. Gruijters MJG, Visser J A, Durlinger ALL and Themmen APN, Anti-Mullerian hormone and its role in ovarian function. Mol Cell Endocrinol, 2003, 211, 85-90
• 11. Weenen C, Layen JS, Von Bergh AR, Cranfield M, Gwome NP, Visser JA, Kramer P, Fauser BC, Themmen AP. Anti-Müllerian hormone expression pattern in the human ovary: potential implications for initial and cyclic follicle recruitment. 2004, 10(2), 77-83
• 12. de Vet A, Laven JS, de Jong FH, Themmen AP and Fauser BC, Antimullerian hormone serum levels: a putative marker for ovarian aging. Fertil Steril, 2002, 77, 357-362
• 13. Fanchin R, Schonauer LM, Righini C, Frydman N, Frydman R and Taieb J, Serum anti-Mullerian hormone dynamics during controlled ovarian hyperstimulation. Hum Reprod, 2003,18, 328—332