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Yıl 2008, Cilt 39, Sayı 3, 131 - 135, 01.04.2008

Öz

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Kaynakça

  • 1. Junqueira L, Carneiro J.Basic Histology ,10 th edition, Lange Medical Books, 2003
  • 2. BabiorB.M., CurnetteJ.T. andMcMurrichB. J. The particulate superoxide-forming system in human neutrophils. J. Clin. Invest. 1976; 58: 989996
  • 3. Lamirande E, Gagnon C. Impact of reactive oxygen species on spermatozoa: a balancing act between beneficial and detrimental effects. Hum. Reprod. 1995; 10(1):15-21
  • 4. Cummins J. M., Jequier A. M. and Kan R. Molecular biology of human male infertility: links with aging, mitochondrial genetics, and oxidative stress? Mol. Reprod. Dev. 1994; 37: 345-362
  • 5. Agarwal A, Saleh RA., Bedaiwy M. Role of reactive oxygen species in the pathophysiology of human reproduction. Fertil. Steril. 2003; 79(4): 829-843
  • 6. Yilmaz S, Koyuturk M, Kiliç G, Alpak O, Aytoz A. Effects of Leukocytospermia on semen parameters and outcomes of intracytoplasmic sperm injection. International Journal of Andrology 2005; 28: 337-347
  • 7. Aitken RJ., Harkiss D, Buckingham DW. Analysis of lipid peroxidation mechanisms in human spermatozoa. Mol. Reprod. Devel. 1993; 35:302-315
  • 8. Geva E, LessingJ. B., Lerner-Geva L., AmitA. Free radicals, antioxidants and human spermatozoa: clinical implications. 1998; 13(6):1422-4
  • 9. Sharma R K, Agarwal A. Role ofreactive oxygen species in male infertility. Clinical review. Urology; 1996; 48(6): 835-850
  • 10. Griveau JF, Lannou D. Reactive oxygen species and human spermatozoa: physiology and pathology. Int. J. Androl. 1997; 20: 61-69
  • 11. Hargreave TB. Male Infertility Second edition, 1994, 94-103
  • 12. HalliwellB. Free radicals, antioxidants, and human disease: curiosity, cause, or consequence? Lancet, 1994; 344: 721-724
  • 13. Erenpreiss J, Hlevicka S, Zalkalns J, Erenpreisa J. Effect of leuckocytospermia on sperm DNA integrity: a negative effect in abnormal semen samples J. Androl. 2002; 23(5):717-723
  • 14. Lopes S, Jurisicova A, Sun J,Casper R. Reactive oxygen species: potential cause for DNA fragmentation in human spermatozoa. Hum. Reprod. 1998; 13(4):896-900
  • 15. Li T. K. The glutathione and thiol content of mammalian spermatozoa and seminal plasma. Biol. Reprod. 1975; 12: 641- 646
  • 16. Nissen H.P.and Kreysel H. W. Superoxide dismutase in human semen, Klin. Wochensch. 1983; 61: 63-65
  • 17. Jeulin c., SoufirJ. C., Weber P., et al. Catalace activity in human spermatozoa and seminal plasma. Gamete Res. 1989; 24: 185-196
  • 18. Byung Pal Yu Cellular defenses against damage from reactive oxygen species. Physiological Reviews 1994;74(1): 139-162
  • 19. DawsonE. B, Harris W.A., TeterM.C. etal. Effect of ascorbic acid supplementation on the sperm quality of smokers. Fertil Steril. 1992; 58: 1034-1039
  • 20. EskenaziB., Kidd SA., Marks AR, Sloter E, Block G., Wyrobek AJ. Antioxidant intake is associated with semen quality in healthy men. Hum. Reprod.2005; 20(4):1006-12
  • 21.www. tiscali.co.uk/lifestyle/healthfitness/mens healthZpart1_4-2.html 22. Gomez E, Aitken J. Impact of in vitro fertilization culture media on peroxidative damage to human spermatozoa. Fertil. Steril. 1996; 65(4):880-2
  • 23. LenziA., CulassoF., GandiniL., etal. Placebo-controlled, doubleblind, cross-over trial of glutathione therapy in male infertility. Hum Reprod. 1993; 8: 1657-1662
  • 24. Geva E., Bartoov B., Zabludovsky N. et al. The effect of antioxidant treatment on human spermatozoa and fertilization rate in an in vitro fertilization program. Fertil Steril. 1996; 66: 430434
  • 25. Warren J.S., Johnson K.J., and Ward P.A., Oxygen radicals in cell injury and cell death. Pathol. Immunopathol. Res. 1987; 6: 301-315
  • 26. Parinaud J., Le Lannou D., Vieitez G., et al. Enhancement of motility by treating spermatozoa with an antioxidant solution (Sperm-Fit) following ejaculation. Hum. Reprod. 1997; 12: 2434-2436

Reactive oxygen species and antioxidants in semen

Yıl 2008, Cilt 39, Sayı 3, 131 - 135, 01.04.2008

Öz

The role of oxygen toxicity and free radical reactions (reactive oxygen species) in association wity fertility potential is known. All cellular elements such as lipids,proteins, nucleic acids and sugars are known to be the potential targets for these radicals. Cytotoxicity of reactive oxygen species is held in check by the delicate balance between their rates of generation and the rate of their removal. Any shift in this equilibrium can lead to cellular damage. The ability of the spermatozoa to prevent lipid peroxidation is of critical importance in maintaining proper function and stability of the cell membrane. Intra and extracellular scavenger systems (antioxidants) serve to prevent the potential toxic effects of reactive oxygen species. Therefore dietary and supplement intake of antioxidants and treating spermatozoa with solutions containing antioxidants during the preparation of semen should be advised during infertility treatment.

Kaynakça

  • 1. Junqueira L, Carneiro J.Basic Histology ,10 th edition, Lange Medical Books, 2003
  • 2. BabiorB.M., CurnetteJ.T. andMcMurrichB. J. The particulate superoxide-forming system in human neutrophils. J. Clin. Invest. 1976; 58: 989996
  • 3. Lamirande E, Gagnon C. Impact of reactive oxygen species on spermatozoa: a balancing act between beneficial and detrimental effects. Hum. Reprod. 1995; 10(1):15-21
  • 4. Cummins J. M., Jequier A. M. and Kan R. Molecular biology of human male infertility: links with aging, mitochondrial genetics, and oxidative stress? Mol. Reprod. Dev. 1994; 37: 345-362
  • 5. Agarwal A, Saleh RA., Bedaiwy M. Role of reactive oxygen species in the pathophysiology of human reproduction. Fertil. Steril. 2003; 79(4): 829-843
  • 6. Yilmaz S, Koyuturk M, Kiliç G, Alpak O, Aytoz A. Effects of Leukocytospermia on semen parameters and outcomes of intracytoplasmic sperm injection. International Journal of Andrology 2005; 28: 337-347
  • 7. Aitken RJ., Harkiss D, Buckingham DW. Analysis of lipid peroxidation mechanisms in human spermatozoa. Mol. Reprod. Devel. 1993; 35:302-315
  • 8. Geva E, LessingJ. B., Lerner-Geva L., AmitA. Free radicals, antioxidants and human spermatozoa: clinical implications. 1998; 13(6):1422-4
  • 9. Sharma R K, Agarwal A. Role ofreactive oxygen species in male infertility. Clinical review. Urology; 1996; 48(6): 835-850
  • 10. Griveau JF, Lannou D. Reactive oxygen species and human spermatozoa: physiology and pathology. Int. J. Androl. 1997; 20: 61-69
  • 11. Hargreave TB. Male Infertility Second edition, 1994, 94-103
  • 12. HalliwellB. Free radicals, antioxidants, and human disease: curiosity, cause, or consequence? Lancet, 1994; 344: 721-724
  • 13. Erenpreiss J, Hlevicka S, Zalkalns J, Erenpreisa J. Effect of leuckocytospermia on sperm DNA integrity: a negative effect in abnormal semen samples J. Androl. 2002; 23(5):717-723
  • 14. Lopes S, Jurisicova A, Sun J,Casper R. Reactive oxygen species: potential cause for DNA fragmentation in human spermatozoa. Hum. Reprod. 1998; 13(4):896-900
  • 15. Li T. K. The glutathione and thiol content of mammalian spermatozoa and seminal plasma. Biol. Reprod. 1975; 12: 641- 646
  • 16. Nissen H.P.and Kreysel H. W. Superoxide dismutase in human semen, Klin. Wochensch. 1983; 61: 63-65
  • 17. Jeulin c., SoufirJ. C., Weber P., et al. Catalace activity in human spermatozoa and seminal plasma. Gamete Res. 1989; 24: 185-196
  • 18. Byung Pal Yu Cellular defenses against damage from reactive oxygen species. Physiological Reviews 1994;74(1): 139-162
  • 19. DawsonE. B, Harris W.A., TeterM.C. etal. Effect of ascorbic acid supplementation on the sperm quality of smokers. Fertil Steril. 1992; 58: 1034-1039
  • 20. EskenaziB., Kidd SA., Marks AR, Sloter E, Block G., Wyrobek AJ. Antioxidant intake is associated with semen quality in healthy men. Hum. Reprod.2005; 20(4):1006-12
  • 21.www. tiscali.co.uk/lifestyle/healthfitness/mens healthZpart1_4-2.html 22. Gomez E, Aitken J. Impact of in vitro fertilization culture media on peroxidative damage to human spermatozoa. Fertil. Steril. 1996; 65(4):880-2
  • 23. LenziA., CulassoF., GandiniL., etal. Placebo-controlled, doubleblind, cross-over trial of glutathione therapy in male infertility. Hum Reprod. 1993; 8: 1657-1662
  • 24. Geva E., Bartoov B., Zabludovsky N. et al. The effect of antioxidant treatment on human spermatozoa and fertilization rate in an in vitro fertilization program. Fertil Steril. 1996; 66: 430434
  • 25. Warren J.S., Johnson K.J., and Ward P.A., Oxygen radicals in cell injury and cell death. Pathol. Immunopathol. Res. 1987; 6: 301-315
  • 26. Parinaud J., Le Lannou D., Vieitez G., et al. Enhancement of motility by treating spermatozoa with an antioxidant solution (Sperm-Fit) following ejaculation. Hum. Reprod. 1997; 12: 2434-2436

Semende reaktif oksijen türevleri ve antioksidanlar

Yıl 2008, Cilt 39, Sayı 3, 131 - 135, 01.04.2008

Öz

Fertilite potansiyeli ile oksijen toksisitesi ve serbest radikallerin (reaktif oksijen türevleri) ilişkisi bilinmektedir. Yağlar, proteinler, nükleik asitler ve şekerler gibi tüm hücresel yapılar reaktif oksijen türevleri için potansiyel hedeflerdir Reaktif oksijen radikallerinin sitotoksisitesi üretilme veyokedilme oranları arasındaki hassas denge sonucu belirlenmektedir. Bu dengedeki herhangi bir bozukluk hücresel zarara neden olmaktadır. Spermatozoaların lipid peroksidasyonundan korunmaları bu hücrelerin fonksiyonlarını doğru bir şekilde yerine getirebilmeleri ve hücre zarlarının devamlılığını koruyabilmeleri açısından çok büyük önem taşımaktadır. Bu durum teorik olarak O2-ve H2O2 seviyeleri sınırlandırılarak, metal katalizörlerinin varlığı sınırlandırarak ve peroksidasyon başladığı anda durdurularak sağlanabilir. Hücre içi ve dışı koruma sistemleri (antioksidanlar) bu amaçla hizmet eden ve serbest radikallerin potansiyel toksik etkilerine karşı hücreyi koruyan mekanizmalardır. Spermatozoonların oksidatifzarar görmemesiya da mümkün olduğunca az zarar görmesi için infertilite tedavisinde diyetle antioksidan alımıya da antioksidan içeren medyumların sperm hazırlama tekniklerinde kullanımı önerilebilir.

Kaynakça

  • 1. Junqueira L, Carneiro J.Basic Histology ,10 th edition, Lange Medical Books, 2003
  • 2. BabiorB.M., CurnetteJ.T. andMcMurrichB. J. The particulate superoxide-forming system in human neutrophils. J. Clin. Invest. 1976; 58: 989996
  • 3. Lamirande E, Gagnon C. Impact of reactive oxygen species on spermatozoa: a balancing act between beneficial and detrimental effects. Hum. Reprod. 1995; 10(1):15-21
  • 4. Cummins J. M., Jequier A. M. and Kan R. Molecular biology of human male infertility: links with aging, mitochondrial genetics, and oxidative stress? Mol. Reprod. Dev. 1994; 37: 345-362
  • 5. Agarwal A, Saleh RA., Bedaiwy M. Role of reactive oxygen species in the pathophysiology of human reproduction. Fertil. Steril. 2003; 79(4): 829-843
  • 6. Yilmaz S, Koyuturk M, Kiliç G, Alpak O, Aytoz A. Effects of Leukocytospermia on semen parameters and outcomes of intracytoplasmic sperm injection. International Journal of Andrology 2005; 28: 337-347
  • 7. Aitken RJ., Harkiss D, Buckingham DW. Analysis of lipid peroxidation mechanisms in human spermatozoa. Mol. Reprod. Devel. 1993; 35:302-315
  • 8. Geva E, LessingJ. B., Lerner-Geva L., AmitA. Free radicals, antioxidants and human spermatozoa: clinical implications. 1998; 13(6):1422-4
  • 9. Sharma R K, Agarwal A. Role ofreactive oxygen species in male infertility. Clinical review. Urology; 1996; 48(6): 835-850
  • 10. Griveau JF, Lannou D. Reactive oxygen species and human spermatozoa: physiology and pathology. Int. J. Androl. 1997; 20: 61-69
  • 11. Hargreave TB. Male Infertility Second edition, 1994, 94-103
  • 12. HalliwellB. Free radicals, antioxidants, and human disease: curiosity, cause, or consequence? Lancet, 1994; 344: 721-724
  • 13. Erenpreiss J, Hlevicka S, Zalkalns J, Erenpreisa J. Effect of leuckocytospermia on sperm DNA integrity: a negative effect in abnormal semen samples J. Androl. 2002; 23(5):717-723
  • 14. Lopes S, Jurisicova A, Sun J,Casper R. Reactive oxygen species: potential cause for DNA fragmentation in human spermatozoa. Hum. Reprod. 1998; 13(4):896-900
  • 15. Li T. K. The glutathione and thiol content of mammalian spermatozoa and seminal plasma. Biol. Reprod. 1975; 12: 641- 646
  • 16. Nissen H.P.and Kreysel H. W. Superoxide dismutase in human semen, Klin. Wochensch. 1983; 61: 63-65
  • 17. Jeulin c., SoufirJ. C., Weber P., et al. Catalace activity in human spermatozoa and seminal plasma. Gamete Res. 1989; 24: 185-196
  • 18. Byung Pal Yu Cellular defenses against damage from reactive oxygen species. Physiological Reviews 1994;74(1): 139-162
  • 19. DawsonE. B, Harris W.A., TeterM.C. etal. Effect of ascorbic acid supplementation on the sperm quality of smokers. Fertil Steril. 1992; 58: 1034-1039
  • 20. EskenaziB., Kidd SA., Marks AR, Sloter E, Block G., Wyrobek AJ. Antioxidant intake is associated with semen quality in healthy men. Hum. Reprod.2005; 20(4):1006-12
  • 21.www. tiscali.co.uk/lifestyle/healthfitness/mens healthZpart1_4-2.html 22. Gomez E, Aitken J. Impact of in vitro fertilization culture media on peroxidative damage to human spermatozoa. Fertil. Steril. 1996; 65(4):880-2
  • 23. LenziA., CulassoF., GandiniL., etal. Placebo-controlled, doubleblind, cross-over trial of glutathione therapy in male infertility. Hum Reprod. 1993; 8: 1657-1662
  • 24. Geva E., Bartoov B., Zabludovsky N. et al. The effect of antioxidant treatment on human spermatozoa and fertilization rate in an in vitro fertilization program. Fertil Steril. 1996; 66: 430434
  • 25. Warren J.S., Johnson K.J., and Ward P.A., Oxygen radicals in cell injury and cell death. Pathol. Immunopathol. Res. 1987; 6: 301-315
  • 26. Parinaud J., Le Lannou D., Vieitez G., et al. Enhancement of motility by treating spermatozoa with an antioxidant solution (Sperm-Fit) following ejaculation. Hum. Reprod. 1997; 12: 2434-2436

Ayrıntılar

Birincil Dil Türkçe
Bölüm Makaleler
Yazarlar

Seda YILMAZ Bu kişi benim


Kenan SOFUOĞLU Bu kişi benim


Nuri DELİKARA Bu kişi benim


Tansel ÇETİNKAYA Bu kişi benim


Elif YILMAZ Bu kişi benim

Yayımlanma Tarihi 1 Nisan 2008
Yayınlandığı Sayı Yıl 2008, Cilt 39, Sayı 3

Kaynak Göster

Bibtex @ { zktipb236932, journal = {Zeynep Kamil Tıp Bülteni}, issn = {1300-7971}, eissn = {2148-4864}, address = {}, publisher = {Zeynep Kamil Kadın ve Çocuk Hastalıkları EAH}, year = {2008}, volume = {39}, pages = {131 - 135}, doi = {10.16948/zktb.86591}, title = {Semende reaktif oksijen türevleri ve antioksidanlar}, key = {cite}, author = {Yılmaz, Seda and Sofuoğlu, Kenan and Delikara, Nuri and Çetinkaya, Tansel and Yılmaz, Elif} }
APA Yılmaz, S. , Sofuoğlu, K. , Delikara, N. , Çetinkaya, T. & Yılmaz, E. (2008). Semende reaktif oksijen türevleri ve antioksidanlar . Zeynep Kamil Tıp Bülteni , 39 (3) , 131-135 . Retrieved from https://dergipark.org.tr/tr/pub/zktipb/issue/22068/236932
MLA Yılmaz, S. , Sofuoğlu, K. , Delikara, N. , Çetinkaya, T. , Yılmaz, E. "Semende reaktif oksijen türevleri ve antioksidanlar" . Zeynep Kamil Tıp Bülteni 39 (2008 ): 131-135 <https://dergipark.org.tr/tr/pub/zktipb/issue/22068/236932>
Chicago Yılmaz, S. , Sofuoğlu, K. , Delikara, N. , Çetinkaya, T. , Yılmaz, E. "Semende reaktif oksijen türevleri ve antioksidanlar". Zeynep Kamil Tıp Bülteni 39 (2008 ): 131-135
RIS TY - JOUR T1 - Semende reaktif oksijen türevleri ve antioksidanlar AU - Seda Yılmaz , Kenan Sofuoğlu , Nuri Delikara , Tansel Çetinkaya , Elif Yılmaz Y1 - 2008 PY - 2008 N1 - DO - T2 - Zeynep Kamil Tıp Bülteni JF - Journal JO - JOR SP - 131 EP - 135 VL - 39 IS - 3 SN - 1300-7971-2148-4864 M3 - UR - Y2 - 2021 ER -
EndNote %0 Zeynep Kamil Tıp Bülteni Semende reaktif oksijen türevleri ve antioksidanlar %A Seda Yılmaz , Kenan Sofuoğlu , Nuri Delikara , Tansel Çetinkaya , Elif Yılmaz %T Semende reaktif oksijen türevleri ve antioksidanlar %D 2008 %J Zeynep Kamil Tıp Bülteni %P 1300-7971-2148-4864 %V 39 %N 3 %R %U
ISNAD Yılmaz, Seda , Sofuoğlu, Kenan , Delikara, Nuri , Çetinkaya, Tansel , Yılmaz, Elif . "Semende reaktif oksijen türevleri ve antioksidanlar". Zeynep Kamil Tıp Bülteni 39 / 3 (Nisan 2008): 131-135 .
AMA Yılmaz S. , Sofuoğlu K. , Delikara N. , Çetinkaya T. , Yılmaz E. Semende reaktif oksijen türevleri ve antioksidanlar. Zeynep Kamil Tıp Bülteni. 2008; 39(3): 131-135.
Vancouver Yılmaz S. , Sofuoğlu K. , Delikara N. , Çetinkaya T. , Yılmaz E. Semende reaktif oksijen türevleri ve antioksidanlar. Zeynep Kamil Tıp Bülteni. 2008; 39(3): 131-135.
IEEE S. Yılmaz , K. Sofuoğlu , N. Delikara , T. Çetinkaya ve E. Yılmaz , "Semende reaktif oksijen türevleri ve antioksidanlar", Zeynep Kamil Tıp Bülteni, c. 39, sayı. 3, ss. 131-135, Nis. 2008, doi:10.16948/zktb.86591