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PROBİYOTİK VE PREBİYOTİK TÜKETİMİNİN LAKTOZ İNTOLERANSI ÜZERİNE ETKİLERİ

Year 2020, Volume: 45 Issue: 2, 380 - 389, 15.01.2020
https://doi.org/10.15237/gida.GD20016

Abstract

Dünya genelinde yüksek oranda görülen laktaz yetersizliğinin tedavi edilmesi veya sebep olduğu olumsuz etkilerin azaltılması üzerine uzun yıllardır çok sayıda çalışma yapılmıştır. Süt tüketiminin mecburen azaltılmasına neden olan laktaz yetersizliğinin temelde genetik faktörlere dayanması, bu rahatsızlığın önlenmesine engel olmaktadır. Ancak önlenemese de süt tüketimine imkan tanıyacak kadar ortaya çıkan rahatsızlıkların kontrol altına alınması mümkündür. Bu nedenle daha çok bu etkileri azaltmaya yönelik alternatif çözümler aranmaktadır. Son yıllarda yapılan araştırmalar, bu amaçla probiyotik ve prebiyotik tüketiminin laktoz intoleransına sahip kişilerde laktaz yetersizliğine bağlı olarak görülen etkileri azalttığını göstermiştir. Bu çalışma kapsamında laktoz intoleransı üzerine probiyotik ve prebiyotik kullanımının etkileri üzerine yapılan araştırmalar incelenmiştir.

References

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  • Amiri, M., Diekmann, L., von Köckritz-Blickwede, M., Naim, H.Y. (2015). The Diverse Forms of Lactose Intolerance and the Putative Linkage to Several Cancers. Nutrients, 7: 7209-7230, doi:10.3390/nu7095332
  • Arnold, J.W., Simpson, J.B., Roach, J., Bruno-Barcena, J.M., Azacarate-Peril, M.A. (2018). Prebiotics for Lactose Intolerance: Variability in Galacto-Oligosaccharide Utilization by Intestinal Lactobacillus rhamnosus. Nutrients, 10: 1517. doi:10.3390/nu10101517.
  • Azcarate-Peril, M.A., Ritter, A.J., Savaiano, D., Monteagudo-Mera, A., Anderson, C., Magness, S.T., Klaenhammer, T.R. (2017). Impact of short-chain galactooligosaccharides on the gut microbiome of lactose-intolerant individuals. Proceedings of the National Academy of Sciences, 114, E367-E375.
  • Bakken, T., Braaten, T., Olsen, A., Hjartåker, A., Lund, E., Skeie, G. (2018). Milk and risk of colorectal, colon and rectal cancer in the Norwegian Women and Cancer (NOWAC) Cohort Study. British Journal of Nutrition, 119: 1274-1285.
  • Barrubes, L., Babio N., Mena-Sanchez G., Toledo E., Ramirez-Sabio J.B., Estruch, R., Ros, E., Fito, M., Aros, F., Fiol, M., Santos-Lozana, J., Serra-Majem, L., Pinto, X., Martınez-Gonzalez, M. A., Sorli, J. V., Basora, J., Salas-Salvado, J. (2018). Dairy product consumption and risk of colorectal cancer in an older Mediterranean population at high cardiovascular risk. International Journal of Cancer, 143: 1356–1366.
  • Bayhan, A. ve Yentür G. (1993). Laktoz İntoleransı. Gıda, 18(6): 385-388.
  • Bayless, T. M., Brown, E., Paige, D. M. (2017). Lactase Non-persistence and Lactose Intolerance. Current Gastroenterology Reports, 19:23. DOI:10.1007/s11894-017-0558-9.
  • Cano‐Contreras, A.D., Pérez y López, N.J., Minero‐Alfaro I., Medina‐López; V.M., Reyes‐Huerta. J. U. (2019). Efficacy of probiotic I3.1 symptomatic improvement in patients with lactose intolerance. Abstracts of the 18th American Neurogastroenterology and Motility Society Annual Scientific Meeting, 16-18 August, Chicago, Illinois, USA.
  • Corgneau, M.M., Scher, J., Ritie-Pertusa, L., Le D.T.L., Petit, J., Nikolova, Y., Banon, S., Gaiani, C. (2017). Recent advances on lactose intolerance: Tolerance thresholds and currently available answers, Critical Reviews in Food Science and Nutrition, 57:15, 3344-3356, DOI:10.1080/10408398.2015.1123671.
  • Costanzo, D. M., Canani, R. B. (2018). Lactose intolerance: Common misunderstandings. Annals of Nutrition and Metabolism, 73 (suppl 4):30-37.
  • Däbritz, J., Mühlbauer, M., Domagk, D., Voos, N., Henneböhl, G., Siemer, M.L., Foell, D. (2014). Significance of hydrogen breath tests in children with suspected carbohydrate malabsorption. BMC Pediatrics.14. doi: 10.1186/1471-2431-14-59.
  • Demirgül, F. ve Demirgül R. (2019). Laktoz intoleransın prevalansı, teşhisi ve laktozsuz beslenme tavsiyeleri. Food and Health, 5(4), 281-290. https://doi.org/10.3153/FH19028.
  • Dhama, K., Latheef, S. K. and Munjal A. K. (2016). Probiotics in curing allergic and inflammatory conditions – Research progress and futuristic vision. Recent Patents on Inflammation & Allergy Drug Discovery, 10 (1):21-33.
  • Domínguez-Jiménez, J.L., Fernández-Suárez, A. (2017). Diagnosis of lactose intolerance. Medicina Clínica, 148(6):262-264.
  • Fassio, F., Facioni, M. S., Guagnini, F. (2018). Lactose Maldigestion, Malabsorption, and Intolerance: A Comprehensive Review with a Focus on Current Management and Future Perspectives. Nutrients, 10: 1599; doi:10.3390/nu10111599.
  • Forsgård, R. A. (2019). Lactose digestion in humans: intestinal lactase appears to be constitutive whereas the colonic microbiome is adaptable. The American Journal of Clinical Nutrition, 110:273-279.
  • Fox, P.F., Uniacke-Lowe, T., McSweeney, P.L.H. and O’Mahony, J.A.M. (2015). Lactose. In: Dairy Chemistry and Biochemistry, 21–68. Springer International Publishing, Cham.
  • Ganesan, K., Chung, S. K., Vanamala, J., Xu, B. (2018). Causal Relationship between Diet-Induced Gut Microbiota Changes and Diabetes: A Novel Strategy to Transplant Faecalibacterium prausnitzii in Preventing Diabetes. International Journal of Molecular Sciences, 19: 3720. doi:10.3390/ijms19123720
  • Gingold-Belfer, R., Levy, S., Layfer, O., Pakanaev, L., Niv, Y., Dickman, R., Parets, T. T. (2019). Use of a Novel Probiotic Formulation to Alleviate Lactose Intolerance Symptoms—a Pilot Study. Probiotics and Antimicrobial Proteins, Jan 7. https://doi.org/10.1007/s12602-018-9507-7. Hajare, S.T., Bekele, G. (2017). Effect of probiotic strain Lactobacillus acidophilus (LBKV-3) on fecal residual lactase activity in undernourished children below 10 years. Journal of Immunoassay and Immunochemistry, 38(6): 620-628.
  • Harvey, L., Ludwig, T., Hou, A. Q., Hock, Q. S., Tan, M. L. N., Osatakul, S., Bindels, J., Muhardi, L. (2018). Prevalence, cause and diagnosis of lactose intolerance in children aged 1–5 years: a systematic review of 1995–2015 literature. Asia Pacific Journal of Clinical Nutrition, 27(1):29-46.
  • He, T., Priebe, M.G., Harmsen, H.J.M., Stellaard, F., Sun, X., Welling, G.W., Vonk, R.J. (2006). Colonic fermentation may play a role in lactose intolerance in humans. The Journal of Nutrition, 136(1): 58-63.
  • He, T., Priebe, M. G., Zhong, Y., Huang, C., Harmsen, H. J. M., Raangs, G. C., Antoine, J. M., Welling, G. W., Vonk, R. J. (2008). Effects of yogurt and bifidobacteria supplementation on the colonic microbiota in lactose-intolerant subjects. Journal of Applied Microbiology, 104: 595–604. doi:10.1111/j.1365-2672.2007.03579.x
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  • Kleniewska, P., Hoffmann, A., Pniewska, E., Pawliczak, R. (2016). The Influence of Probiotic Lactobacillus casei in combination with prebiotic ınulin on the antioxidant capacity of human plasma. Oxidative Medicine and Cellular Longevity, 2016:1340903.
  • Latorre, G., Besa, P., Parodi, C.G., Ferrer, V., Azocar, L., Quirola, M. and Chianale, J. (2014). Prevalence of lactose intolerance in Chile: a double-blind placebo study. Digestion, 90(1): 18-26.
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  • Mahboubi, M., Kazempour, N. (2016). The effects of inulin on characteristics of Lactobacillus paracasei TD3 (IBRC-M 10784) as probiotic bacteria in vitro. Archives of Iranian Medicine, 19(2): 92-95.
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  • Mustapha, A., Jiang, T., Savaiano, D.A. (1997). Improvement of lactose digestion by humans following ingestion of unfermented acidophilus milk: influence of bile sensitivity, lactose transport, and acid tolerance of Lactobacillus acidophilus. Journal of Dairy Science, 80:1537-1545.
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THE EFFECTS OF PROBIOTIC AND PREBIOTIC CONSUMPTION ON LACTOSE INTOLERANCE

Year 2020, Volume: 45 Issue: 2, 380 - 389, 15.01.2020
https://doi.org/10.15237/gida.GD20016

Abstract

For many years, different studies have been conducted on the treatment or reducing the harmful effects of lactase deficiency, which is prevailing all around the world. Lactase deficiency, which causes to reduce milk consumption, is mainly based on genetic factors, and they inhibit the prevention of this disease. However, even if it cannot be prevented, it is possible to control the disorders that occur to allow milk consumption. Therefore, alternative methods are being sought to reduce these effects. Recent studies have shown that probiotics and prebiotic consumption reduces the impacts of lactase deficiency in people with lactose intolerance. This paper reviews the studies on the effects of probiotic and prebiotic use on lactose intolerance.

References

  • Almeida, C.C., Lorena, S.L.S., Pavan, C.R., Akasaka, H.M.I., Mesquita, M.A. (2012). Beneficial effects of long-term consumption of a probiotic combination of Lactobacillus casei shirota and Bifidobacterium breve yakult may persist after suspension of therapy in lactose-intolerant patients. Nutrition in Clinical Practice, 27: 247–251.
  • Amiri, M., Diekmann, L., von Köckritz-Blickwede, M., Naim, H.Y. (2015). The Diverse Forms of Lactose Intolerance and the Putative Linkage to Several Cancers. Nutrients, 7: 7209-7230, doi:10.3390/nu7095332
  • Arnold, J.W., Simpson, J.B., Roach, J., Bruno-Barcena, J.M., Azacarate-Peril, M.A. (2018). Prebiotics for Lactose Intolerance: Variability in Galacto-Oligosaccharide Utilization by Intestinal Lactobacillus rhamnosus. Nutrients, 10: 1517. doi:10.3390/nu10101517.
  • Azcarate-Peril, M.A., Ritter, A.J., Savaiano, D., Monteagudo-Mera, A., Anderson, C., Magness, S.T., Klaenhammer, T.R. (2017). Impact of short-chain galactooligosaccharides on the gut microbiome of lactose-intolerant individuals. Proceedings of the National Academy of Sciences, 114, E367-E375.
  • Bakken, T., Braaten, T., Olsen, A., Hjartåker, A., Lund, E., Skeie, G. (2018). Milk and risk of colorectal, colon and rectal cancer in the Norwegian Women and Cancer (NOWAC) Cohort Study. British Journal of Nutrition, 119: 1274-1285.
  • Barrubes, L., Babio N., Mena-Sanchez G., Toledo E., Ramirez-Sabio J.B., Estruch, R., Ros, E., Fito, M., Aros, F., Fiol, M., Santos-Lozana, J., Serra-Majem, L., Pinto, X., Martınez-Gonzalez, M. A., Sorli, J. V., Basora, J., Salas-Salvado, J. (2018). Dairy product consumption and risk of colorectal cancer in an older Mediterranean population at high cardiovascular risk. International Journal of Cancer, 143: 1356–1366.
  • Bayhan, A. ve Yentür G. (1993). Laktoz İntoleransı. Gıda, 18(6): 385-388.
  • Bayless, T. M., Brown, E., Paige, D. M. (2017). Lactase Non-persistence and Lactose Intolerance. Current Gastroenterology Reports, 19:23. DOI:10.1007/s11894-017-0558-9.
  • Cano‐Contreras, A.D., Pérez y López, N.J., Minero‐Alfaro I., Medina‐López; V.M., Reyes‐Huerta. J. U. (2019). Efficacy of probiotic I3.1 symptomatic improvement in patients with lactose intolerance. Abstracts of the 18th American Neurogastroenterology and Motility Society Annual Scientific Meeting, 16-18 August, Chicago, Illinois, USA.
  • Corgneau, M.M., Scher, J., Ritie-Pertusa, L., Le D.T.L., Petit, J., Nikolova, Y., Banon, S., Gaiani, C. (2017). Recent advances on lactose intolerance: Tolerance thresholds and currently available answers, Critical Reviews in Food Science and Nutrition, 57:15, 3344-3356, DOI:10.1080/10408398.2015.1123671.
  • Costanzo, D. M., Canani, R. B. (2018). Lactose intolerance: Common misunderstandings. Annals of Nutrition and Metabolism, 73 (suppl 4):30-37.
  • Däbritz, J., Mühlbauer, M., Domagk, D., Voos, N., Henneböhl, G., Siemer, M.L., Foell, D. (2014). Significance of hydrogen breath tests in children with suspected carbohydrate malabsorption. BMC Pediatrics.14. doi: 10.1186/1471-2431-14-59.
  • Demirgül, F. ve Demirgül R. (2019). Laktoz intoleransın prevalansı, teşhisi ve laktozsuz beslenme tavsiyeleri. Food and Health, 5(4), 281-290. https://doi.org/10.3153/FH19028.
  • Dhama, K., Latheef, S. K. and Munjal A. K. (2016). Probiotics in curing allergic and inflammatory conditions – Research progress and futuristic vision. Recent Patents on Inflammation & Allergy Drug Discovery, 10 (1):21-33.
  • Domínguez-Jiménez, J.L., Fernández-Suárez, A. (2017). Diagnosis of lactose intolerance. Medicina Clínica, 148(6):262-264.
  • Fassio, F., Facioni, M. S., Guagnini, F. (2018). Lactose Maldigestion, Malabsorption, and Intolerance: A Comprehensive Review with a Focus on Current Management and Future Perspectives. Nutrients, 10: 1599; doi:10.3390/nu10111599.
  • Forsgård, R. A. (2019). Lactose digestion in humans: intestinal lactase appears to be constitutive whereas the colonic microbiome is adaptable. The American Journal of Clinical Nutrition, 110:273-279.
  • Fox, P.F., Uniacke-Lowe, T., McSweeney, P.L.H. and O’Mahony, J.A.M. (2015). Lactose. In: Dairy Chemistry and Biochemistry, 21–68. Springer International Publishing, Cham.
  • Ganesan, K., Chung, S. K., Vanamala, J., Xu, B. (2018). Causal Relationship between Diet-Induced Gut Microbiota Changes and Diabetes: A Novel Strategy to Transplant Faecalibacterium prausnitzii in Preventing Diabetes. International Journal of Molecular Sciences, 19: 3720. doi:10.3390/ijms19123720
  • Gingold-Belfer, R., Levy, S., Layfer, O., Pakanaev, L., Niv, Y., Dickman, R., Parets, T. T. (2019). Use of a Novel Probiotic Formulation to Alleviate Lactose Intolerance Symptoms—a Pilot Study. Probiotics and Antimicrobial Proteins, Jan 7. https://doi.org/10.1007/s12602-018-9507-7. Hajare, S.T., Bekele, G. (2017). Effect of probiotic strain Lactobacillus acidophilus (LBKV-3) on fecal residual lactase activity in undernourished children below 10 years. Journal of Immunoassay and Immunochemistry, 38(6): 620-628.
  • Harvey, L., Ludwig, T., Hou, A. Q., Hock, Q. S., Tan, M. L. N., Osatakul, S., Bindels, J., Muhardi, L. (2018). Prevalence, cause and diagnosis of lactose intolerance in children aged 1–5 years: a systematic review of 1995–2015 literature. Asia Pacific Journal of Clinical Nutrition, 27(1):29-46.
  • He, T., Priebe, M.G., Harmsen, H.J.M., Stellaard, F., Sun, X., Welling, G.W., Vonk, R.J. (2006). Colonic fermentation may play a role in lactose intolerance in humans. The Journal of Nutrition, 136(1): 58-63.
  • He, T., Priebe, M. G., Zhong, Y., Huang, C., Harmsen, H. J. M., Raangs, G. C., Antoine, J. M., Welling, G. W., Vonk, R. J. (2008). Effects of yogurt and bifidobacteria supplementation on the colonic microbiota in lactose-intolerant subjects. Journal of Applied Microbiology, 104: 595–604. doi:10.1111/j.1365-2672.2007.03579.x
  • Hegar, B., Widodo A. (2015). Lactose intolerance in Indonesian children. Asia Pacific Journal of Clinical Nutrition. 215, 24(Suppl 1):S31-40. doi: 10.6133/apjcn.2015.24.s1.06. Kim, J.W. (2017). Lactose intolerance and colorectal cancer. Annals of Coloproctology, 33(5):157-158.
  • Kleniewska, P., Hoffmann, A., Pniewska, E., Pawliczak, R. (2016). The Influence of Probiotic Lactobacillus casei in combination with prebiotic ınulin on the antioxidant capacity of human plasma. Oxidative Medicine and Cellular Longevity, 2016:1340903.
  • Latorre, G., Besa, P., Parodi, C.G., Ferrer, V., Azocar, L., Quirola, M. and Chianale, J. (2014). Prevalence of lactose intolerance in Chile: a double-blind placebo study. Digestion, 90(1): 18-26.
  • Liu, F., Li, P., Chen, M., Luo, Y., Prabhakar, M., Zheng, H., He, Y., Qi, Q., Long, H., Zhang, Y., Sheng, H., Zhou, H. (2017). Fructooligosaccharide (FOS) and galactooligosaccharide (GOS) increase Bifidobacterium but reduce butyrate producing bacteria with adverse glycemic metabolism in healthy young population. Scientific Reports, 7: 11789.
  • Ma, J., Giovannucci, E., Pollak, M., Chan, J. M., Gaziano, J. M., Willett, W., Stampfer, M. J. (2001). Milk intake, circulating levels of insulin-like growth factor-1, and risk of colorectal cancer in men. Journal of the National Cancer Institute, 93: 1330-1336.
  • Mahboubi, M., Kazempour, N. (2016). The effects of inulin on characteristics of Lactobacillus paracasei TD3 (IBRC-M 10784) as probiotic bacteria in vitro. Archives of Iranian Medicine, 19(2): 92-95.
  • Melini, F., Melini, V., Luziatelli, F., Ficca, A. G., Ruzzi, M. (2019). Health-promoting components in fermented foods: An up-to-date systematic review. Nutrients 11: 1189. Metin, M. (2005). Süt Teknolojisi Sütün bileşimi ve işlenmesi. Ege Üniversitesi Basımevi, İzmir, 802 s. Moens, F., Weckx, S., Vuyst, L. D. (2016). Bifidobacterial inulin-type fructan degradation capacity determines cross-feeding interactions between bifidobacteria and Faecalibacterium prausnitzii. International Journal of Food Microbiology, 231: 76-85.
  • Minale, P., Hiller, J., Kramer, M. F., Heath, M., Justicia, J. L. (2019). Symbiotics as a new perspective in the treatment of lactose intolerance. Annals of Nutrition and Metabolism, 74(suppl 1):1-31.
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There are 55 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Ceren Akal

Atilla Yetişmeyen

Publication Date January 15, 2020
Published in Issue Year 2020 Volume: 45 Issue: 2

Cite

APA Akal, C., & Yetişmeyen, A. (2020). PROBİYOTİK VE PREBİYOTİK TÜKETİMİNİN LAKTOZ İNTOLERANSI ÜZERİNE ETKİLERİ. Gıda, 45(2), 380-389. https://doi.org/10.15237/gida.GD20016
AMA Akal C, Yetişmeyen A. PROBİYOTİK VE PREBİYOTİK TÜKETİMİNİN LAKTOZ İNTOLERANSI ÜZERİNE ETKİLERİ. The Journal of Food. January 2020;45(2):380-389. doi:10.15237/gida.GD20016
Chicago Akal, Ceren, and Atilla Yetişmeyen. “PROBİYOTİK VE PREBİYOTİK TÜKETİMİNİN LAKTOZ İNTOLERANSI ÜZERİNE ETKİLERİ”. Gıda 45, no. 2 (January 2020): 380-89. https://doi.org/10.15237/gida.GD20016.
EndNote Akal C, Yetişmeyen A (January 1, 2020) PROBİYOTİK VE PREBİYOTİK TÜKETİMİNİN LAKTOZ İNTOLERANSI ÜZERİNE ETKİLERİ. Gıda 45 2 380–389.
IEEE C. Akal and A. Yetişmeyen, “PROBİYOTİK VE PREBİYOTİK TÜKETİMİNİN LAKTOZ İNTOLERANSI ÜZERİNE ETKİLERİ”, The Journal of Food, vol. 45, no. 2, pp. 380–389, 2020, doi: 10.15237/gida.GD20016.
ISNAD Akal, Ceren - Yetişmeyen, Atilla. “PROBİYOTİK VE PREBİYOTİK TÜKETİMİNİN LAKTOZ İNTOLERANSI ÜZERİNE ETKİLERİ”. Gıda 45/2 (January 2020), 380-389. https://doi.org/10.15237/gida.GD20016.
JAMA Akal C, Yetişmeyen A. PROBİYOTİK VE PREBİYOTİK TÜKETİMİNİN LAKTOZ İNTOLERANSI ÜZERİNE ETKİLERİ. The Journal of Food. 2020;45:380–389.
MLA Akal, Ceren and Atilla Yetişmeyen. “PROBİYOTİK VE PREBİYOTİK TÜKETİMİNİN LAKTOZ İNTOLERANSI ÜZERİNE ETKİLERİ”. Gıda, vol. 45, no. 2, 2020, pp. 380-9, doi:10.15237/gida.GD20016.
Vancouver Akal C, Yetişmeyen A. PROBİYOTİK VE PREBİYOTİK TÜKETİMİNİN LAKTOZ İNTOLERANSI ÜZERİNE ETKİLERİ. The Journal of Food. 2020;45(2):380-9.

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