Anti-infective effect of Aquilaria malaccensis L. essential oil against Candida strains, the leading cause of yeast infectious

Year 2025, Volume: 9 Issue: 2, 325 - 330, 26.06.2025

Tuba Unver , Ayşe Şebnem Özalp Erenler , Tuğba Raika Kıran

https://doi.org/10.31015/2025.2.7

Abstract

Aquilaria malaccensis L., known as Agarwood, is widely found in India, Malaysia, Bhutan, and Indonesia. It is a pleasantly scented plant used in the production of resin. It is an interesting material in the field of health due to its resin and essential oil, which exhibit antimicrobial properties. This study aimed to evaluate the antifungal properties of A. malaccensis L. essential oil and determine its minimum inhibitory concentrations (MIC) against the Candida species tested. The inhibitory effect of A. malaccensis L. essential oil was tested on five Candida species. The broth microdilution method was used to determine the MIC values against the tested microorganisms, and the viability of microorganisms exposed to the plant essential oil was assessed using resazurin sodium salt. According to the results, the MIC of the plant essential oil against Candida tropicalis, Candida krusei and Candida albicans is 62.50 µL/mL. While the MIC against Candida glabrata is 31.25 µL/mL, the MIC against Candida parapsilosis is 7.81 µL/mL. These results show the potential of A. malaccensis L. as an anti-candidal agent. The continuation of this study revealed the need for optimizing and implementing more comprehensive antimicrobial tests.

Keywords

Aquilaria malaccensis L. , Agarwood , Anti-candidal activity , Candidiasis , MIC value

Ethical Statement

Peer-review Externally peer-reviewed. Declaration of Interests The authors declare no conflicts of interest. Author contribution All authors declare that they have participated in the design, execution, and analysis of the study and have approved the final version.

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