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Corynoline as a Bioactive Natural Alkaloid: Molecular Mechanisms and Therapeutic Potential

Cilt: 9 Sayı: 2 25 Haziran 2026
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Corynoline as a Bioactive Natural Alkaloid: Molecular Mechanisms and Therapeutic Potential

Öz

Corynoline is a bioactive isoquinoline alkaloid isolated primarily from plants of the Corydalis species and has attracted increasing attention due to its diverse pharmacological properties. Accumulating experimental evidence suggests that corynoline exhibits anti-inflammatory, cytoprotective and anticancer activities through the modulation of oxidative stress, mitochondrial function and key cellular signalling pathways. Recent studies indicate that corynoline can influence cellular energy metabolism, redox balance and cell survival mechanisms, positioning it as a promising candidate for diseases characterized by metabolic dysregulation, including cancer and ischemic organ injury. In particular, its effects on tumor cell proliferation, apoptosis and metabolic adaptation highlight its potential relevance in aggressive malignancies such as glioblastoma, where therapeutic resistance and metabolic plasticity remain major challenges. This review summarizes the current knowledge on the chemical characteristics, molecular targets and biological effects of corynoline with a special focus on its role in cancer biology and organ-protective mechanisms. In addition, existing limitations, gaps in translational research and future therapeutic perspectives are discussed to provide a comprehensive framework for further preclinical and clinical investigations.

Anahtar Kelimeler

Corynoline, natural alkaloids, cancer metabolism, oxidative stress, mitochondrial function, cytoprotection

Destekleyen Kurum

Düzce University Scientific Research Projects (BAP) and the Coordinator of Environmental and Health Technologies Specialization.

Proje Numarası

2026.1.1.8.

Etik Beyan

This study did not involve any human participants or animals. Therefore, ethics committee approval was not required.

Teşekkür

The author expresses her sincere gratitude to Düzce University Scientific Research Projects (BAP) and the Coordinator of Environmental and Health Technologies Specialization for their invaluable support through Project No. 2026.1.1.8. This funding was instrumental in facilitating the research presented in this review.

Kaynakça

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  2. Awad, A. M. A. M., & Abdul Karim, N. (2025). Dysregulation of Mitochondrial Function in Cancer Cells. In International Journal of Molecular Sciences (Vol. 26, Number 14). Multidisciplinary Digital Publishing Institute (MDPI). https://doi.org/10.3390/ijms26146750
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  6. Iranshahy, M., Quinn, R. J., & Iranshahi, M. (2014). Biologically active isoquinoline alkaloids with drug-like properties from the genus Corydalis. In RSC Advances (Vol. 4, Number 31, pp. 15900–15913). https://doi.org/10.1039/c3ra47944g
  7. Jin, C., Yu, X. Bin, Yang, J., Lin, Z., Ma, R. X., Lin, B. H., Zhang, H. J., Dai, Z. H., Xue, K., Xie, C. L., Zheng, W., Feng, Y., Xiao, J., & Yang, L. (2024). Corynoline Suppresses Osteoclastogenesis and Attenuates ROS Activities by Regulating NF-κB/MAPKs and Nrf2 Signaling Pathways. Journal of Agricultural and Food Chemistry, 72(14), 8149–8166. https://doi.org/10.1021/acs.jafc.3c07088
  8. Kang, H., & Kim, B. (2023). Bioactive Compounds as Inhibitors of Inflammation, Oxidative Stress and Metabolic Dysfunctions via Regulation of Cellular Redox Balance and Histone Acetylation State. In Foods (Vol. 12, Number 5). MDPI. https://doi.org/10.3390/foods12050925
  9. Kovacheva, E., Gevezova, M., Koeva, M., Mihaylova, V., Kormova, V., Kostadinova, E., Kostadinova, Y., Kazakova, M., & Sarafian, V. (2025). Mitochondrial Function, Oxidative Stress, Inflammation and Thrombolytic Treatment in Ischemic Stroke. International Journal of Molecular Sciences, 26(21). https://doi.org/10.3390/ijms262110289
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Kaynak Göster

APA
Ağan, A. F. (2026). Corynoline as a Bioactive Natural Alkaloid: Molecular Mechanisms and Therapeutic Potential. Journal of Apitherapy and Nature, 9(2), 152-160. https://doi.org/10.35206/jan.1967127
AMA
1.Ağan AF. Corynoline as a Bioactive Natural Alkaloid: Molecular Mechanisms and Therapeutic Potential. Journal of Apitherapy and Nature. 2026;9(2):152-160. doi:10.35206/jan.1967127
Chicago
Ağan, Aydan Fülden. 2026. “Corynoline as a Bioactive Natural Alkaloid: Molecular Mechanisms and Therapeutic Potential”. Journal of Apitherapy and Nature 9 (2): 152-60. https://doi.org/10.35206/jan.1967127.
EndNote
Ağan AF (01 Haziran 2026) Corynoline as a Bioactive Natural Alkaloid: Molecular Mechanisms and Therapeutic Potential. Journal of Apitherapy and Nature 9 2 152–160.
IEEE
[1]A. F. Ağan, “Corynoline as a Bioactive Natural Alkaloid: Molecular Mechanisms and Therapeutic Potential”, Journal of Apitherapy and Nature, c. 9, sy 2, ss. 152–160, Haz. 2026, doi: 10.35206/jan.1967127.
ISNAD
Ağan, Aydan Fülden. “Corynoline as a Bioactive Natural Alkaloid: Molecular Mechanisms and Therapeutic Potential”. Journal of Apitherapy and Nature 9/2 (01 Haziran 2026): 152-160. https://doi.org/10.35206/jan.1967127.
JAMA
1.Ağan AF. Corynoline as a Bioactive Natural Alkaloid: Molecular Mechanisms and Therapeutic Potential. Journal of Apitherapy and Nature. 2026;9:152–160.
MLA
Ağan, Aydan Fülden. “Corynoline as a Bioactive Natural Alkaloid: Molecular Mechanisms and Therapeutic Potential”. Journal of Apitherapy and Nature, c. 9, sy 2, Haziran 2026, ss. 152-60, doi:10.35206/jan.1967127.
Vancouver
1.Aydan Fülden Ağan. Corynoline as a Bioactive Natural Alkaloid: Molecular Mechanisms and Therapeutic Potential. Journal of Apitherapy and Nature. 01 Haziran 2026;9(2):152-60. doi:10.35206/jan.1967127