Helicobacter pylori ENFEKSİYONUNDA PROBİYOTİKLERİN ROLÜ

Yıl 2018, Cilt: 43 Sayı: 6, 943 - 956, 01.11.2018

Vildan Akdeniz A. Sibel Akalın Elif Özer

https://doi.org/10.15237/gida.GD18062

Cited By: 5

Öz

Dünya Sağlık Örgütü tarafından kanserojen grupta
sınıflandırılan Helicobacter pylori enfeksiyonu yüksek tekrarlanma
sıklığı ile hem gelişmekte olan hem de gelişmiş ülkelerde görülen önemli bir
halk sağlığı sorunudur. H. pylori'nin mide mukozasında kolonize olarak
kronik gastritin ana nedenini oluşturduğu bilinmektedir. Mide mikrobiyotası H.
pylori’nin sebep olduğu hastalıkların oluşmasında ve gelişmesinde önemli
bir rol oynamaktadır. Beslenme düzenindeki değişimlerle gastrik mukozadaki H.
pylori yoğunluğunda azalma sağlanması, H. pylori ile ilişkili peptik
ülser, kronik gastrit, mide adenokarsinoması, mukoza ile ilişkili lenfoid doku
lenfoması ve duodenal ülser hastalığı gibi hastalıkların ortaya çıkma riskini
azaltmaya yardımcı olacaktır. H. pylori enfeksiyonunda antibiyotik
tedavisi uygulanmakta, fakat bu süreçte antibiyotik direnci ve antibiyotik tedavisinin
yan etkileri görülebilmektedir. Yapılan çalışmalar bağırsak mikrobiyotası
üzerinde olumlu etkiye sahip olan probiyotiklerin; H. pylori enfeksiyonu
tedavisinde eradikasyon oranını arttırdığını, hasta klinik belirtilerini
iyileştirdiğini ve tedaviye bağlı antibiyotik ile ilişkili yan etkileri
azaltarak hasta uyumunu arttırdığını belirtmektedir.  

Anahtar Kelimeler

Helicobacter pylori, probiyotik, antibiyotik tedavisi

ROLE OF PROBIOTICS IN Helicobacter pylori INFECTION

Öz

Helicobacter pylori infection which is recognized as carcinogen by WHO is a
major public health problem in both developing and developed countries with
high prevalence. It is well known that H. pylori causes mainly to
chronic gastritis colonising in the gastric mucosa. Gastric microbiota is
important in the occurrence and development of diseases caused by H. pylori.
Nutritional modification providing a reduction in the population of H.
pylori at the gastric mucosa will help to decrease the risk of H. pylori-associated
diseases including peptic ulcer, chronic gastritis, gastric adenocarcinoma,
mucosa associated lymphoid tissue lymphoma and duodenal ulcer disease.
Antibiotic therapy is applied in this infection, but meanwhile it’s side
effects and antibiotic resistance be seen. Studies indicate that probiotics
which have positive effects on intestinal microbiota increase eradication rates
of H. pylori, improve patient clinical symptoms and improve patient
compliance by reducing side effects associated with antibiotic treatment.

Anahtar Kelimeler

Helicobacter pylori, probiotic, antibiotic treatment

Kaynakça

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